[gmx-users] Problems with the Dihedral of the Ethanol

David van der Spoel spoel at xray.bmc.uu.se
Thu Aug 3 14:09:14 CEST 2006


Eudes Fileti wrote:
> Dear gmx users
> I have attemped to simulate a box of ethanol in normal conditions of 
> temperature and pressure.
> I reproduced very well some literature data (as g(r)) however I had 
> problems to reproduce the angular
> distribution function for the dihedral (C-C-O-H).
> This angle must have a peak in 180 degrees and two lesser (and 
> symmetrical) peaks in 60 and 300 degrees (as shows the figure 1 of this 
> link http://cbio.mskcc.org/~leonor/jpcb97.pdf ).
> However my distribution presents a maximum in 100 degrees with two (but 
> not symmetrical) peaks the left.
> I already made almost everything:
> I used both, dihedral GROMACS and Ryckaert-Bellemans, I applied almost 
> all the avaliables parameters
> (eg in ffoplsaabon.itp), I set nrexcl 2, 3, 4, 5, I remade the 
> simulation several times in with differents conditions, but always I 
> found the same pattern.
> Somebody already had some experience like that? If it had, could you 
> give me a insight? Bellow I give my top file.
> Thank you in advance.
> eef
> 
> ;
> ;    File 'etanol.top' was generated
> ;    By user: fileti (1000)
> ;    On host: linux
> ;    At date: Sat Jul 15 16:41:25 2006
> ;
> ;    This is your topology file
> ;    "Out Of Register Space (Ugh)" (Vi)
> ;
> ; Include forcefield parameters
> #include "ffoplsaa.itp"
> 
> [ moleculetype ]
> ; Name            nrexcl
> ETH                 2
> 
> [ atoms ]
> ;   nr       type  resnr residue  atom   cgnr     charge       mass  
> typeB    chargeB      massB
>      1   opls_135      1   EtOH     CB      1      -0.18     12.011   ; 
> qtot -0.18
>      2   opls_140      1   EtOH    HB1      1       0.06      1.008   ; 
> qtot -0.12
>      3   opls_140      1   EtOH    HB2      1       0.06      1.008   ; 
> qtot -0.06
>      4   opls_140      1   EtOH    HB3      1       0.06      1.008   ; 
> qtot 0
>      5   opls_157      1   EtOH     CA      2      0.145     12.011   ; 
> qtot 0.145
>      6   opls_140      1   EtOH    HA1      2       0.06      1.008   ; 
> qtot 0.205
>      7   opls_140      1   EtOH    HA2      2       0.06      1.008   ; 
> qtot 0.265
>      8   opls_154      1   EtOH     OH      2     - 0.683    15.9994   ; 
> qtot -0.418
>      9   opls_155      1   EtOH     HO      2      0.418      1.008   ; 
> qtot 0
> 
> [ bonds ]
> ;  ai    aj funct             c0       c1 
>     1     2     1          0.10800   284512.0
>     1     3     1          0.10800   284512.0
>     1     4     1          0.10800   284512.0
>     1     5     1          0.14040   392459.2
>     5     6     1          0.10800   307105.6
>     5     7     1          0.10800   307105.6
>     5     8     1          0.13640   376560.0
>     8     9     1          0.09450   462750.4
> 
> [ angles ]
> ;  ai    aj    ak funct            c0        c1 
>     2     1     3     1         107.800    276.144
>     2     1     4     1         107.800    276.144
>     2     1     5     1         107.800    276.144
>     3     1     4     1         107.800    276.144
>     3     1     5     1         110.700     313.800
>     4     1     5     1         110.700    313.800
>     1     5     6     1         109.500    292.880
>     1     5     7     1         109.500    292.880
>     1     5     8     1         109.500    418.400
>     6     5     7     1         107.800    276.144
>     6     5     8     1         115.000    334.720 
>     7     5     8     1         108.000    585.760
>     5     8     9     1         109.000    292.880
> 
> [ dihedrals ]
> ;  ai    aj    ak    al funct            c0        c1        c2        
> c3        c4        c5
>     2     1     5     6     3         1.67360  -1.67360   0.00000   
> 0.00000   0.00000   0.00000
>     2     1     5     7     3         1.67360  -1.67360   0.00000   
> 0.00000   0.00000   0.00000
>     2     1     5     8     3         0.97905   2.93716   0.00000  
> -3.91622   0.00000   0.00000
>     3     1     5     6     3         1.67360  -1.67360   0.00000    
> 0.00000   0.00000   0.00000
>     3     1     5     7     3         1.67360  -1.67360   0.00000   
> 0.00000   0.00000   0.00000
>     3     1     5     8     3         0.97905   2.93716   0.00000  
> -3.91622   0.00000   0.00000
>     4     1     5     6     3         1.67360  -1.67360   0.00000   
> 0.00000   0.00000   0.00000
>     4     1     5     7     3         1.67360  -1.67360   0.00000   
> 0.00000   0.00000   0.00000
>     4     1     5     8     3         0.97905   2.93716   0.00000  
> -3.91622   0.00000   0.00000
>     1     5     8     9     3        26.15000  -3.13800 -23.01200   
> 0.00000   0.00000   0.00000
>     6     5     8     9     3         0.94140   2.82420   0.00000   
> -3.76560   0.00000   0.00000
>     7     5     8     9     3         0.94140   2.82420   0.00000  
> -3.76560   0.00000   0.00000
> 
> 
> ______________________________________
>                                       Eudes Eterno Fileti
>           Centro de Ciência Naturais e Humanas
>                         Universidade Federal do ABC
>                                   Rua Santa Adélia, 166
>                                             CEP 09210-170
>                                                skype: eefileti
> 
> 
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-- 
David.
________________________________________________________________________
David van der Spoel, PhD, Assoc. Prof., Molecular Biophysics group,
Dept. of Cell and Molecular Biology, Uppsala University.
Husargatan 3, Box 596,  	75124 Uppsala, Sweden
phone:	46 18 471 4205		fax: 46 18 511 755
spoel at xray.bmc.uu.se	spoel at gromacs.org   http://folding.bmc.uu.se
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