[gmx-users] ITD-Modelling

[Mark Abraham]

> Hello mailing-list!
>
> Actually I'm about to create a model of a tyrosine-receptor-kinase
> (named FLT3 - pdb-code: 1rjb). However, the problem is that I have to
> model a mutation of this receptor. A point mutation would be easy to
> handle, but in my case the receptor contains a so called "internal
> tandem duplication" which is an insert whose length is ~13-30 amino
> acids at a specific point. The origin of the inserted sequence is from
> the same exon, so the native folding-structure of this sequence within
> the wild type is known.

So the native and the insert structures are known....

> Any suggestions how to model such a ITD-sequence into a wild type
> receptor?

... so what's the problem?

Mark