[gmx-users] Error in pdb2gmx.....Atom CE2 not found in residue PHE270 while adding hydrogens

vivek sharma viveksharma.iitb at gmail.com
Wed Aug 13 10:37:23 CEST 2008


Hi There,

For the error I mentioned in last mail I looked in the .rtp file and .pdb
file for residue NDP. Following is the part of .pdb file showing atoms as
PA, O1A etc

HETATM 8111  PA  NDP     1       8.809  -4.754  22.676  1.00 12.71
HETATM 8112  O1A NDP     1      10.106  -4.137  23.158  1.00 11.98
HETATM 8113  O2A NDP     1       8.869  -5.751  21.580  1.00 13.09
HETATM 8114  O5B NDP     1       8.010  -5.348  23.937  1.00 12.91
HETATM 8115  C5B NDP     1       6.913  -6.239  23.752  1.00 12.91
HETATM 8116  C4B NDP     1       6.493  -6.754  25.120  1.00 10.44
HETATM 8117  O4B NDP     1       5.292  -7.535  24.969  1.00 13.02
HETATM 8118  C3B NDP     1       7.588  -7.667  25.612  1.00 10.90
HETATM 8119  O3B NDP     1       7.552  -7.543  27.047  1.00 12.99
HETATM 8120  C2B NDP     1       7.086  -9.053  25.407  1.00 12.38
HETATM 8121  O2B NDP     1       7.660 -10.046  26.246  1.00 13.11
HETATM 8122  C1B NDP     1       5.579  -8.877  25.356  1.00 12.53
HETATM 8123  N9A NDP     1       4.817  -9.905  24.673  1.00 11.65
HETATM 8124  C8A NDP     1       5.033 -10.388  23.429  1.00 10.38
HETATM 8125  N7A NDP     1       4.132 -11.360  23.119  1.00 11.50
HETATM 8126  C5A NDP     1       3.332 -11.498  24.179  1.00 10.26
HETATM 8127  C6A NDP     1       2.217 -12.337  24.568  1.00 11.19
HETATM 8128  N6A NDP     1       1.746 -13.251  23.689  1.00 12.10
HETATM 8129  N1A NDP     1       1.678 -12.169  25.805  1.00 11.24
HETATM 8130  C2A NDP     1       2.130 -11.262  26.690  1.00 10.83
HETATM 8131  N3A NDP     1       3.161 -10.439  26.428  1.00 10.06
HETATM 8132  C4A NDP     1       3.776 -10.558  25.154  1.00 11.15
HETATM 8133  O3  NDP     1       7.769  -3.631  22.173  1.00 12.62
HETATM 8134  PN  NDP     1       7.989  -2.036  22.130  1.00 12.08
HETATM 8135  O1N NDP     1       8.430  -1.526  23.461  1.00 11.89
HETATM 8136  O2N NDP     1       8.741  -1.692  20.889  1.00 11.73
HETATM 8137  O5D NDP     1       6.467  -1.533  21.886  1.00 12.66
HETATM 8138  C5D NDP     1       5.611  -1.361  23.020  1.00 11.65
HETATM 8139  C4D NDP     1       4.298  -0.748  22.582  1.00 11.67
HETATM 8140  O4D NDP     1       4.556   0.487  21.875  1.00 12.21
HETATM 8141  C3D NDP     1       3.548  -1.649  21.637  1.00 11.97
HETATM 8142  O3D NDP     1       2.175  -1.497  22.010  1.00 11.22
HETATM 8143  C2D NDP     1       3.579  -0.984  20.290  1.00 12.02
HETATM 8144  O2D NDP     1       2.475  -1.229  19.433  1.00 11.31
HETATM 8145  C1D NDP     1       3.974   0.454  20.593  1.00 12.46
HETATM 8146  N1N NDP     1       4.714   1.092  19.529  1.00 11.43
HETATM 8147  C2N NDP     1       6.045   0.998  19.502  1.00 11.26
HETATM 8148  C3N NDP     1       6.724   1.599  18.453  1.00 10.05
HETATM 8149  C7N NDP     1       8.217   1.540  18.362  1.00 11.67
HETATM 8150  O7N NDP     1       8.756   2.105  17.403  1.00 11.17
HETATM 8151  N7N NDP     1       8.916   0.848  19.266  1.00 11.33
HETATM 8152  C4N NDP     1       6.022   2.270  17.471  1.00 10.99
HETATM 8153  C5N NDP     1       4.641   2.345  17.528  1.00 11.46
HETATM 8154  C6N NDP     1       4.005   1.748  18.602  1.00 12.11
HETATM 8155  P2B NDP     1       7.584 -11.626  25.952  1.00 13.18
HETATM 8156  O1X NDP     1       8.540 -12.200  26.975  1.00 15.49
HETATM 8157  O2X NDP     1       6.162 -12.049  26.180  1.00 13.31
HETATM 8158  O3X NDP     1       8.073 -11.835  24.534  1.00 13.10

......and following is the part of .rtp file for details of residue NDP

[ NDPH ]
 [ atoms ]
   AP     P     0.76000     0
 AO1P    OM    -0.63500     0
 AO2P    OM    -0.63500     0
 AO5*    OA    -0.36000     0
  O3P    OA    -0.26000     1
   NP     P     0.76000     1
 NO1P    OM    -0.63500     1
 NO2P    OM    -0.63500     1
 NO5*    OA    -0.36000     1
 AC5*   CH2     0.00000     2
 AC4*   CH1     0.16000     3
 AO4*    OA    -0.36000     3
 AC1*   CH1     0.20000     3
  AN9    NR    -0.20000     4
  AC4     C     0.20000     4
  AN3    NR    -0.36000     5
  AC2   CR1     0.36000     5
  AN1    NR    -0.36000     6
  AC6     C     0.36000     6
  AN6    NT    -0.83000     7
 AH61     H     0.41500     7
 AH62     H     0.41500     7
  AC5     C     0.00000     8
  AN7    NR    -0.36000     8
  AC8   CR1     0.36000     8
 AC2*   CH1     0.15000     9
 AO2*    OA    -0.36000     9
 AP2*     P     0.63000     9
 AO6*    OM    -0.63500     9
 AO7*    OM    -0.63500     9
 AO8*    OA    -0.54800     9
 AH8*     H     0.39800     9
 AC3*   CH1     0.15000    10
 AO3*    OA    -0.54800    10
 AH3*     H     0.39800    10
 NC5*   CH2     0.00000    11
 NC4*   CH1     0.16000    12
 NO4*    OA    -0.36000    12
 NC1*   CH1     0.20000    12
  NN1    NR    -0.20000    13
  NC6   CR1     0.20000    13
  NC2   CR1     0.00000    13
  NC3     C     0.00000    13
  NC4   CH2     0.00000    13
  NC5   CR1     0.00000    13
  NC7     C     0.38000    14
  NO7     O    -0.38000    14
  NN7    NT    -0.83000    15
 NH71     H     0.41500    15
 NH72     H     0.41500    15
 NC2*   CH1     0.15000    16
 NO2*    OA    -0.54800    16
 NH2*     H     0.39800    16
 NC3*   CH1     0.15000    17
 NO3*    OA    -0.54800    17
 NH3*     H     0.39800    17

are those file indicating some error like atom name are different in two
files, is this the reason for my error or I have to think in some other way.

Any advice would be of great help.

With Thanx,
Vivek

2008/8/13 vivek sharma <viveksharma.iitb at gmail.com>

> Hi Nahren,
> Thanx for your help, I opened the pdb file with swisspdb viewer and then
> tried the pdb2gmx command over that pdb file and got the following error.
>
> Total mass 28295.072 a.m.u.
> Total charge 1.000 e
> Writing topology
> Processing chain 5 'E' (372 atoms, 9 residues)
> There are 0 donors and 0 acceptors
> There are 0 hydrogen bonds
> Warning: 'NDP' not found in residue topology database, trying to use 'NDPH'
>
> -------------------------------------------------------
> Program pdb2gmx, VERSION 3.3.3
> Source code file: pdb2gmx.c, line: 421
>
> Fatal error:
> Atom PA in residue NDPH 1 not found in rtp entry with 56 atoms
>              while sorting atoms
> -------------------------------------------------------
>
> and the error for the all atom forcefield were as follow.
>
> -------------------------------------------------------
> Program pdb2gmx, VERSION 3.3.3
> Source code file: resall.c, line: 436
>
> Fatal error:
> Residue 'NDP' not found in residue topology database
>
> -------------------------------------------------------
>
>
> any advice for this will be of great help for me.
>
> Thanx,
> Vivek
>
> 2008/8/12 nahren manuel <meetnahren at yahoo.com>
>
>  Dear Vivek,
>> you just have to download swisspdb and open your pdb file. Thats all you
>> got to do and It is more than enough. If you have more than 2/3 residues
>> missing then, make sure the Ramachandran plots are fine. Also try a simple
>> minimization before begining gromacs.
>>
>> nahren
>>
>> --- On *Tue, 8/12/08, vivek sharma <viveksharma.iitb at gmail.com>* wrote:
>>
>> From: vivek sharma <viveksharma.iitb at gmail.com>
>> Subject: Re: [gmx-users] Error in pdb2gmx.....Atom CE2 not found in
>> residue PHE270 while adding hydrogens
>> To: "Discussion list for GROMACS users" <gmx-users at gromacs.org>
>> Date: Tuesday, August 12, 2008, 6:34 PM
>>
>>
>>  Hi David,
>> Thanx a lot again. can you please tell me the criteria or the standards to
>> do such correction or can you suggest some link or tutorial for the same?
>> whether swiss pdb can help in such cases?
>>
>> With Thanx,
>> Vivek
>>
>>
>>
>> 2008/8/12 David van der Spoel <spoel at xray.bmc.uu.se>
>>
>>>  vivek sharma wrote:
>>>
>>>> Hi There,
>>>>
>>>> I am new to molecular dynamics and GROMACS.
>>>> While trying MD for 1XU9.pdb (pdbid) in the very 1st step on using the
>>>> command....
>>>>
>>>>  pdb2gmx -f 1XU9.pdb -o 1XU9.gro -p 1XU9.top -i 1XU9.itp -vsite hydrogen
>>>> -water spce
>>>>
>>>> I got the following in the last of error.....
>>>> ......
>>>> ......
>>>> ......
>>>> .......
>>>> N-terminus: NH3+
>>>> C-terminus: COO-
>>>> WARNING: atom CE2 not found in residue 270 while adding atom
>>>>
>>>> -------------------------------------------------------
>>>> Program pdb2gmx, VERSION 3.3.3
>>>> Source code file: genhydro.c, line: 304
>>>>
>>>> Fatal error:
>>>> Atom CE2 not found in residue PHE270 while adding hydrogens
>>>> -------------------------------------------------------
>>>>  I tried the same with different force field and water models, but
>>>> getting the same error again and again.
>>>> any suggestion will be highly appreciated.
>>>>
>>>
>>> You have an incorrect pdb file. An atom is missing. You have to fix it
>>> yourself.
>>>
>>>>
>>>>
>>>> With thanx,
>>>> Vivek
>>>>
>>>> ------------------------------------------------------------------------
>>>>
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>>>
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