[gmx-users] Error in pdb2gmx.....Atom CE2 not found in residue PHE270 while adding hydrogens

vivek sharma viveksharma.iitb at gmail.com
Wed Aug 13 15:04:59 CEST 2008


Hi Justin,
Thanx for your suggestion. But, I am not getting how to do correction in
those files I am using gromacs 3.3.3 and 1XU9.pdb molecule for my
simulation.
I am not getting what is happening in the simulation...:(...:(
kindly suggest.

With Thanx,
Vivek


2008/8/13 Justin A. Lemkul <jalemkul at vt.edu>

> There are two potential solutions to this error.  For background, refer to:
>
>
> http://wiki.gromacs.org/index.php/Errors#Residue_.27XXX.27_not_found_in_residue_topology_database
>
> So your options are:
>
> 1. If the ligand is present in the .rtp file, make sure your atom
> nomenclature corresponds to that of the force field.
> 2. Remove the ligand and deal with its topology separately (search Google
> for John Kerrigan's tutorial for enzyme-ligand systems).
>
> -Justin
>
> vivek sharma wrote:
>
>> Hi Nahren,
>> Thanx for your help, I opened the pdb file with swisspdb viewer and then
>> tried the pdb2gmx command over that pdb file and got the following error.
>>
>> Total mass 28295.072 a.m.u.
>> Total charge 1.000 e
>> Writing topology
>> Processing chain 5 'E' (372 atoms, 9 residues)
>> There are 0 donors and 0 acceptors
>> There are 0 hydrogen bonds
>> Warning: 'NDP' not found in residue topology database, trying to use
>> 'NDPH'
>>
>> -------------------------------------------------------
>> Program pdb2gmx, VERSION 3.3.3
>> Source code file: pdb2gmx.c, line: 421
>>
>> Fatal error:
>> Atom PA in residue NDPH 1 not found in rtp entry with 56 atoms
>>             while sorting atoms
>> -------------------------------------------------------
>>
>> and the error for the all atom forcefield were as follow.
>>
>> -------------------------------------------------------
>> Program pdb2gmx, VERSION 3.3.3
>> Source code file: resall.c, line: 436
>>
>> Fatal error:
>> Residue 'NDP' not found in residue topology database
>>
>> -------------------------------------------------------
>>
>> any advice for this will be of great help for me.
>>
>> Thanx,
>> Vivek
>>
>> 2008/8/12 nahren manuel <meetnahren at yahoo.com <mailto:
>> meetnahren at yahoo.com>>
>>
>>    Dear Vivek,
>>    you just have to download swisspdb and open your pdb file. Thats all
>>    you got to do and It is more than enough. If you have more than 2/3
>>    residues missing then, make sure the Ramachandran plots are fine.
>>    Also try a simple minimization before begining gromacs.
>>        nahren
>>
>>    --- On *Tue, 8/12/08, vivek sharma /<viveksharma.iitb at gmail.com
>>    <mailto:viveksharma.iitb at gmail.com>>/* wrote:
>>
>>        From: vivek sharma <viveksharma.iitb at gmail.com
>>        <mailto:viveksharma.iitb at gmail.com>>
>>        Subject: Re: [gmx-users] Error in pdb2gmx.....Atom CE2 not found
>>        in residue PHE270 while adding hydrogens
>>        To: "Discussion list for GROMACS users" <gmx-users at gromacs.org
>>        <mailto:gmx-users at gromacs.org>>
>>        Date: Tuesday, August 12, 2008, 6:34 PM
>>
>>
>>        Hi David,
>>        Thanx a lot again. can you please tell me the criteria or the
>>        standards to do such correction or can you suggest some link or
>>        tutorial for the same?
>>        whether swiss pdb can help in such cases?
>>
>>        With Thanx,
>>        Vivek
>>
>>
>>
>>        2008/8/12 David van der Spoel <spoel at xray.bmc.uu.se
>>        <mailto:spoel at xray.bmc.uu.se>>
>>
>>            vivek sharma wrote:
>>
>>                Hi There,
>>
>>                I am new to molecular dynamics and GROMACS.
>>                While trying MD for 1XU9.pdb (pdbid) in the very 1st
>>                step on using the command....
>>
>>                 pdb2gmx -f 1XU9.pdb -o 1XU9.gro -p 1XU9.top -i 1XU9.itp
>>                -vsite hydrogen -water spce
>>
>>                I got the following in the last of error.....
>>                ......
>>                ......
>>                ......
>>                .......
>>                N-terminus: NH3+
>>                C-terminus: COO-
>>                WARNING: atom CE2 not found in residue 270 while adding
>> atom
>>
>>                -------------------------------------------------------
>>                Program pdb2gmx, VERSION 3.3.3
>>                Source code file: genhydro.c, line: 304
>>
>>                Fatal error:
>>                Atom CE2 not found in residue PHE270 while adding hydrogens
>>                -------------------------------------------------------
>>                 I tried the same with different force field and water
>>                models, but getting the same error again and again.
>>                any suggestion will be highly appreciated.
>>
>>
>>            You have an incorrect pdb file. An atom is missing. You have
>>            to fix it yourself.
>>
>>
>>
>>                With thanx,
>>                Vivek
>>
>>
>>  ------------------------------------------------------------------------
>>
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>
> --
> ========================================
>
> Justin A. Lemkul
> Graduate Research Assistant
> Department of Biochemistry
> Virginia Tech
> Blacksburg, VA
> jalemkul[at]vt.edu | (540) 231-9080
> http://www.bevanlab.biochem.vt.edu/Pages/Personal/justin
>
> ========================================
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