[gmx-users] missing of methyl at N-terminal

Justin A. Lemkul jalemkul at vt.edu
Fri Nov 7 13:10:02 CET 2008



Bhawana Gupta wrote:
> thankyou for ur reply.
> exact error which i m getting, when running pdb2gmx command with the pdb 
> which i had taken from insightII is
> Program pdb2gmx, VERSION 4.0
> Source code file: pdb2gmx.c, line: 429
> 
> Fatal error:
> Atom C in residue NH2 6 not found in rtp entry with 3 atoms
>              while sorting atoms
> 

This probably comes about because you are trying to use parameters from an -NH2 
group on a structure that contains -NH(CH3).  You also haven't mentioned which 
force field you're trying to use.  Some force fields do not have an N-methyl 
group parameterized (check the .rtp file).

-Justin

> 
> this is my pdb in text editor
> there is a presence of 25 atom in my pdb (C in residue NH2 6), but i m 
> getting the error mentioned above
> AUTHOR    GENERATED BY OPEN BABEL 2.2.0
> ATOM      1  CA  ACE     1      -3.811  -0.502   0.471  1.00  
> 0.00           C  
> ATOM      2  C   ACE     1      -2.354  -0.410   0.072  1.00  
> 0.00           C  
> ATOM      3  O   ACE     1      -1.743  -1.403  -0.345  1.00  
> 0.00           O  
> ATOM      4  N   ALA     2      -1.649   0.885   0.183  1.00  
> 0.00           N  
> ATOM      5  CA  ALA     2      -0.244   1.035  -0.187  1.00  
> 0.00           C  
> ATOM      6  C   ALA     2       0.221   2.456   0.023  1.00  
> 0.00           C  
> ATOM      7  O   ALA     2      -0.530   3.334   0.466  1.00  
> 0.00           O  
> ATOM      8  CB  ALA     2      -0.094   0.568  -1.645  1.00  
> 0.00           C  
> ATOM      9  N   ALA     3       1.482   2.703  -0.281  1.00  
> 0.00           N  
> ATOM     10  CA  ALA     3       2.069   4.031  -0.129  1.00  
> 0.00           C  
> ATOM     11  C   ALA     3       3.519   4.033  -0.548  1.00  
> 0.00           C  
> ATOM     12  O   ALA     3       4.081   3.015  -0.969  1.00  
> 0.00           O  
> ATOM     13  CB  ALA     3       1.870   4.463   1.334  1.00  
> 0.00           C  
> ATOM     14  N   ALA     4       4.149   5.189  -0.449  1.00  
> 0.00           N  
> ATOM     15  CA  ALA     4       5.553   5.340  -0.819  1.00  
> 0.00           C  
> ATOM     16  C   ALA     4       6.019   6.761  -0.609  1.00  
> 0.00           C  
> ATOM     17  O   ALA     4       5.267   7.638  -0.166  1.00  
> 0.00           O  
> ATOM     18  CB  ALA     4       5.704   4.872  -2.277  1.00  
> 0.00           C  
> ATOM     19  N   ALA     5       7.279   7.008  -0.913  1.00  
> 0.00           N  
> ATOM     20  CA  ALA     5       7.866   8.336  -0.760  1.00  
> 0.00           C  
> ATOM     21  C   ALA     5       9.317   8.337  -1.179  1.00  
> 0.00           C  
> ATOM     22  O   ALA     5       9.879   7.319  -1.601  1.00  
> 0.00           O  
> ATOM     23  CB  ALA     5       7.668   8.768   0.703  1.00  
> 0.00           C  
> ATOM     24  N   NHM     6      10.022   9.633  -1.069  1.00  
> 0.00           N  
> ATOM     25  C   NHM     6      11.417   9.736  -1.462  1.00  
> 0.00           C 
> CONECT    1    2                                                      
> CONECT    2    3    4    1                                            
> CONECT    3    2                                                      
> CONECT    4    5    2                                                 
> CONECT    5    8    6    4                                            
> CONECT    6    9    5    7                                            
> CONECT    7    6                                                      
> CONECT    8    5                                                      
> CONECT    9   10    6                                                 
> CONECT   10   11    9   13                                            
> CONECT   11   12   14   10                                            
> CONECT   12   11                                                      
> CONECT   13   10                                                      
> CONECT   14   15   11                                                 
> CONECT   15   18   16   14                                            
> CONECT   16   19   15   17                                            
> CONECT   17   16                                                      
> CONECT   18   15                                                      
> CONECT   19   20   16                                                 
> CONECT   20   21   19   23                                            
> CONECT   21   22   24   20                                            
> CONECT   22   21                                                      
> CONECT   23   20                                                      
> CONECT   24   25   21                                                 
> CONECT   25   24                                                      
> MASTER        0    0    0    0    0    0    0    0   25    0   25    0
> END
> 
> Please help me out.
> 
> With regards
> Bhawana
> 
> 
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-- 
========================================

Justin A. Lemkul
Graduate Research Assistant
Department of Biochemistry
Virginia Tech
Blacksburg, VA
jalemkul[at]vt.edu | (540) 231-9080
http://www.bevanlab.biochem.vt.edu/Pages/Personal/justin

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