[gmx-users] Extended structure for Estrogen receptor

Mark Abraham Mark.Abraham at anu.edu.au
Thu Oct 8 00:05:56 CEST 2009

Pradip Biswas wrote:
> Dear All,
> All the estrogen receptor alpha structure that I found on PDB 
> repository, contain mainly the ligand binding domain (residues 301-550). 
> I am looking for a structure that has the hinge region (240-300) as 
> well. Does anyone have any extended structure (even if it is an 
> engineered one) of Estrogen Receptor Alpha which contains the ligand 
> binding domain plus the hinge region residues: 240-550 ??   

Ligand binding domains can be disordered, which makes them unsuited for 
X-ray or NMR structure determination. Thus they might be missing from 
the results or indeed excised before structure determination. Read the 
comments in the PDB files and/or literature to see.


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