[gmx-users] OPLS-AA topologies for ATP

BIN ZHANG zhngbn at gmail.com
Tue Jun 22 18:19:11 CEST 2010


Hi,

I recently made up a topology for ADP. You can probably modify it to  
ATP easily.
I used native OPLS atom types based on the DNA parameters (http://rnp-group.genebee.msu.su/3d/ff.htm 
). The charges are copied from CHARMM27. Also, there is one dihedral  
angle missing, again, copied from CHARMM.
Please let me know if you have any question, suggestion, ....

Cheers,
Bin

===============================
In the ffoplsaa.rtp file, I added:

[ ADP ]
  [ atoms ]
     PB    opls_440   1.100     0 ;P
    O1B    opls_441  -0.900     1 ;O
    O2B    opls_441  -0.900     2 ;O
    O3B    opls_441  -0.900     3 ;O
     PA    opls_440   1.500     4 ;P
    O1A    opls_441  -0.820     5 ;O2
    O2A    opls_441  -0.820     6 ;O2
    O3A    opls_442  -0.740     7 ;OS
    O5'    opls_442  -0.620     8 ;OS
    C5'    opls_443  -0.080     9 ;CT
   H5''    opls_444   0.090    10 ;HC
   H5'     opls_444   0.090    11 ;HC
    C4'    opls_158   0.160    12 ;CT
    H4'    opls_156   0.090    13 ;HC
    O4'    opls_180  -0.500    14 ;OS
    C1'    opls_158   0.160    15 ;CT
    H1'    opls_156   0.090    16 ;HC
     N9    opls_354  -0.050    17 ;NA
     C8    opls_353   0.340    18 ;CK
     H8    opls_359   0.120    19 ;H5
     N7    opls_352  -0.710    20 ;NB
     C5    opls_350   0.280    21 ;CB
     C6    opls_351   0.460    22 ;CA
     N6    opls_356  -0.770    23 ;N2
    H61    opls_357   0.380    24 ;H
    H62    opls_358   0.380    25 ;H
     N1    opls_346  -0.740    26 ;NC
     C2    opls_347   0.500    27 ;CQ
     H2    opls_355   0.130    28 ;H5
     N3    opls_348  -0.750    29 ;NC
     C4    opls_349   0.430    30 ;CB
    C2'    opls_158   0.140    31 ;CT
   H2''    opls_156   0.090    32 ;HC
    O2'    opls_171  -0.660    33 ;OH
    H2'    opls_172   0.430    34 ;HO
    C3'    opls_158   0.140    35 ;CT
    H3'    opls_156   0.090    36 ;HC
    O3'    opls_171  -0.660    37 ;OS
    H3T    opls_172   0.430    38
  [ bonds ]
    PB    O3A
    PB    O1B
    PB    O2B
    PB    O3B
   O3A     PA
    PA    O1A
    PA    O2A
    PA    O5'
   O3'    H3T
   O5'    C5'
   C5'    C4'
   C4'    O4'
   C4'    C3'
   O4'    C1'
   C1'     N9
   C1'    C2'
    N9     C4
    N9     C8
    C4     N3
    C2     N1
    C6     N6
    N6    H61
    N6    H62
    C6     C5
    C5     N7
   C2'    C3'
   C2'    O2'
   O2'    H2'
   C3'    O3'
   C1'    H1'
   C2'   H2''
   C3'    H3'
   C4'    H4'
   C5'    H5'
   C5'   H5''
    C8     H8
    C2     H2
    N1     C6
    N3     C2
    C4     C5
    N7     C8
===============================

===============================
In the ffoplsaabon.itp file, I added:
; copied from ffoplsaanr
[ angletypes ]
   NA     CT     OS      1   109.500    418.680   ; DNA DCY

[ dihedraltypes ]
; these are again copied from ffoplsaanr
   NA      C     CM     CT      3     30.35430   0.00000 -30.35430    
0.00000   0.00000   0.00000 ; aromatic ring DNA DTH
   C      CM     CT     HC      3     -0.77874  -2.33623   0.00000    
3.11498   0.00000   0.00000 ; aromatic ring DNA DTH
   HC     CT     CT     NA      3      0.97134   2.91401   0.00000   
-3.88535   0.00000   0.00000 ; RNA  NA     CT     CT     OH      3      
16.74720 -16.74720   0.00000   0.00000   0.00000   0.00000 ; RNA
   CM     NA     CT     OS      3     -3.14010  -3.14010   6.28020    
0.00000   0.00000   0.00000 ; DNA DCY
   C      NA     CT     OS      3     -3.14010  -3.14010   6.28020    
0.00000   0.00000   0.00000 ; DNA DCY
   CT     OS     CT     NA      3     -5.23350   7.32690   6.28020   
-8.37360   0.00000   0.00000 ;

[ dihedraltypes ]
; copied from charmm
   O2   P    OS  P  1   0.0       0.1255    3.0
   O2   P    OS  P  1   0.0       0.4184    2.0
   OS   P    OS  P  1   0.0       0.1255    3.0
   OS   P    OS  P  1   0.0       0.1255    2.0

===============================
On Jun 22, 2010, at 5:07 AM, Efrat Noy wrote:

> Hi,
>
> Does anyone have OPLS-AA topologies for ATP?
>
> Thanks, Efrat
> -- 
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