[gmx-users] Re: PRODRG server

Justin A. Lemkul jalemkul at vt.edu
Sat Oct 16 16:27:16 CEST 2010



mohsen ramezanpour wrote:
> Dear justin
> no,I had not done it.
> But this two warning are not present in other my molecules,for example I 
> tested another molecule but the massage was:
> 
>                             defaults to zero instead of generating an error
> 
> PRODRG> 
> PRODRG> 
> PRODRG> Starting up PRODRG version 071121.0636
> PRODRG> PRODRG written/copyrighted by Daan van Aalten
> PRODRG> and Alexander Schuettelkopf
> PRODRG> 
> PRODRG> Questions/comments to dava at davapc1.bioch.dundee.ac.uk <mailto:dava at davapc1.bioch.dundee.ac.uk>
> 
> PRODRG> 
> PRODRG> When using this software in a publication, cite:
> PRODRG> A. W. Schuettelkopf and D. M. F. van Aalten (2004).
> PRODRG> PRODRG - a tool for high-throughput crystallography
> PRODRG> of protein-ligand complexes.
> 
> PRODRG> Acta Crystallogr. D60, 1355--1363.
> PRODRG> 
> PRODRG> 
> PRODRG> PDB mode detected.
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> 
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> 
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> 
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> 
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> PRODRG> WARNING: deleted hydrogen  H   from your input.
> 
> PRODRG> WARNING: duplicate atom name F   .
> PRODRG> WARNING: duplicate atom name C   .
> PRODRG> WARNING: atoms with same name found. Auto-renaming.
> PRODRG> Molecule complexity index: 2.09.
> PRODRG>   2 explicit hydrogen(s) added.
> 
> PRODRG>  25 bonds                4 ambiguous
> PRODRG>  36 bond angles         20 ambiguous
> PRODRG>  18 improper dihedrals   0 ambiguous
> PRODRG>   7 dihedrals            2 ambiguous
> PRODRG>   7 partial charges      4 ambiguous
> 
> PRODRG> Net charge on molecule:   0.000
> PRODRG> Using charge groups.
> PRODRG> Writing GROMACS topology.
> PRODRG> GROMACS topology quality on 0-10 scale:  5.7
> GENDRG> Best structure was iteration  931 with   7.66034174
> 
> PRODRG> Spawning GROMACS version 3.3.3...
> PRODRG> RMSD from GROMOS bond ideality (Angstrom) :   0.019
> PRODRG> RMSD from GROMOS angle ideality (degrees) :   2.332
> PRODRG> RMSD from GROMOS plane ideality (degrees) :   1.169
> 
> PRODRG> Number of improper improper dihedrals     :       0
> PRODRG> RMSD from starting bonds (Angstrom)  :   0.036
> PRODRG> RMSD from starting angles (degrees)  :   3.155
> PRODRG> RMSD from starting planes (degrees)  :   1.494
> 
> PRODRG> RMSD from starting coords (Angstrom) :   1.930
> PRODRG> Writing: SCRHWMMPG
> Unfortunately PRODRG crashed
> 
> beside I have done these 6 month ago.exactly with this molecules and I could recieve zip files from server.
> 
> but I can not do the same action with the same files?what do you think?
> 

Sounds like the PRODRG server is having issues.  Try contacting the PRODRG 
developers directly.  You won't be able to get sufficient support on this forum.

-Justin

> 
> PRODRG> Normal program end
> 
> 
> 
> On Sat, Oct 16, 2010 at 4:04 PM, Justin A. Lemkul <jalemkul at vt.edu 
> <mailto:jalemkul at vt.edu>> wrote:
> 
> 
>     These error messages are likely more important:
> 
> 
>     PRODRG> WARNING: multiplicity of generated molecule is not 1.
>     PRODRG> WARNING: bond type assignment failed at C13
> 
>     There is something about the chemical structure involving this atom
>     that PRODRG can't handle.  Based on the information you've provided,
>     however, there's no real way anyone can give you much advice.  Have
>     you tried drawing the molecule with the JME editor provided by
>     PRODRG instead of using a .pdb file?
> 
>     -Justin
> 
>     mohsen ramezanpour wrote:
> 
>         actually the final massage was :Unfortunately PRODRG crashed
> 
>         On Sat, Oct 16, 2010 at 11:36 AM, mohsen ramezanpour
>         <ramezanpour.mohsen at gmail.com
>         <mailto:ramezanpour.mohsen at gmail.com>
>         <mailto:ramezanpour.mohsen at gmail.com
>         <mailto:ramezanpour.mohsen at gmail.com>>> wrote:
> 
>            Dear gromacs users
> 
>            I have a pdb file who include protein and a drug.I separated
>         them by
>            pymol software and saved them separately.now I want to make
>         topology
>            and gro file for it but
>            I am facing with this page below.can you guid me?
>            thanks in advance.
> 
>            PRODRG> Starting up PRODRG version 071121.0636
>            PRODRG> PRODRG written/copyrighted by Daan van Aalten
>            PRODRG> and Alexander Schuettelkopf
>            PRODRG>     PRODRG> Questions/comments to
>         dava at davapc1.bioch.dundee.ac.uk
>         <mailto:dava at davapc1.bioch.dundee.ac.uk>
>         <mailto:dava at davapc1.bioch.dundee.ac.uk
>         <mailto:dava at davapc1.bioch.dundee.ac.uk>>
> 
> 
> 
>            PRODRG>     PRODRG> When using this software in a
>         publication, cite:
>            PRODRG> A. W. Schuettelkopf and D. M. F. van Aalten (2004).
>            PRODRG> PRODRG - a tool for high-throughput crystallography
>            PRODRG> of protein-ligand complexes.
> 
> 
>            PRODRG> Acta Crystallogr. D60, 1355--1363.
>            PRODRG>     PRODRG>     PRODRG> PDB mode detected.
>            PRODRG> WARNING: deleted hydrogen  H1  from your input.
>            PRODRG> Molecule complexity index: 2.17.
> 
> 
>            PRODRG>   1 explicit hydrogen(s) added.
>            PRODRG>  27 bonds                7 ambiguous
>            PRODRG>  40 bond angles         18 ambiguous
>            PRODRG>  19 improper dihedrals   0 ambiguous
>            PRODRG>   9 dihedrals            5 ambiguous
> 
> 
>            PRODRG>   5 partial charges      0 ambiguous
>            PRODRG> Net charge on molecule:   1.000
>            PRODRG> Using charge groups.
>            PRODRG> WARNING: multiplicity of generated molecule is not 1.
>            PRODRG> WARNING: bond type assignment failed at C13  .
> 
> 
>            PRODRG> Writing GROMACS topology.
>            PRODRG> GROMACS topology quality on 0-10 scale:  6.2
>            PRODRG> Keeping old coordinates.
>            PRODRG> RMSD from GROMOS bond ideality (Angstrom) :   0.038
>            PRODRG> RMSD from GROMOS angle ideality (degrees) :   2.230
> 
> 
>            PRODRG> RMSD from GROMOS plane ideality (degrees) :   0.886
>            PRODRG> Number of improper improper dihedrals     :       0
>            PRODRG> Writing: SCRHWMMPG
>            PRODRG> Normal program end
> 
>            best
>            Mohsen
> 
>                        
> 
>          
>          ------------------------------------------------------------------------
> 
> 
> 
>     -- 
>     ========================================
> 
>     Justin A. Lemkul
>     Ph.D. Candidate
>     ICTAS Doctoral Scholar
>     MILES-IGERT Trainee
>     Department of Biochemistry
>     Virginia Tech
>     Blacksburg, VA
>     jalemkul[at]vt.edu <http://vt.edu> | (540) 231-9080
>     http://www.bevanlab.biochem.vt.edu/Pages/Personal/justin
> 
>     ========================================
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-- 
========================================

Justin A. Lemkul
Ph.D. Candidate
ICTAS Doctoral Scholar
MILES-IGERT Trainee
Department of Biochemistry
Virginia Tech
Blacksburg, VA
jalemkul[at]vt.edu | (540) 231-9080
http://www.bevanlab.biochem.vt.edu/Pages/Personal/justin

========================================



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