[gmx-users] intermolecular distance restrains

Justin A. Lemkul jalemkul at vt.edu
Fri Sep 3 14:13:02 CEST 2010


I would suggest filing a bugzilla.  It appears that the -chainsep option is not 
as flexible as might be desired.

-Justin

nahren manuel wrote:
> Dear Gromacs Users,
> 
> Justin, I took your advice and using 4.5.1.
> 
> I have attached the PDB file for your consideration.
> http://www.4shared.com/file/RwF_wuja/chainABCRST.html
> 
> Command :    newpdb2gmx -f chainABCRST.pdb -p dimertop.top -o 
> dimerpdb.pdb -chainsep interactive -ignh
> 
> 8: CHARMM27 all-atom force field (with CMAP) - version 2.0beta 
> (forcefield selected)
> 
> 6: None (water model)
> 
> Reading chainABCRST.pdb...
> Read 6636 atoms
> Analyzing pdb file
> Splitting PDB chains based on TER records or changing chain id.
> Merge chain ending with residue LEU144 (chain id 'A', atom 1444 OXT) with
> chain starting with residue LYS284 (chain id 'B', atom 1445 N)? [n/y]
> y
> Merge chain ending with residue LEU427 (chain id 'B', atom 2888 OXT) with
> chain starting with residue LYS567 (chain id 'C', atom 2889 N)? [n/y]
> y
> Merge chain ending with residue LEU710 (chain id 'C', atom 4332 OXT) with
> chain starting with residue CYS145 (chain id 'R', atom 1 N)? [n/y]
> n
> Merge chain ending with residue CYS283 (chain id 'R', atom 1400 OXT) with
> chain starting with residue CYS428 (chain id 'S', atom 1401 N)? [n/y]
> y
> Merge chain ending with residue CYS566 (chain id 'S', atom 2800 OXT) with
> chain starting with residue CYS711 (chain id 'T', atom 2801 N)? [n/y]
> y
> 
> Program newpdb2gmx, VERSION 4.5.1
> Source code file: pdb2gmx.c, line: 655
> 
> Fatal error:
> Atom OXT in residue LEU 427 was not found in rtp entry LEU with 19 atoms
> while sorting atoms.
> 
> *********
> But this selection works (for the same above command, 1 )
> 
> Merge chain ending with residue LEU144 (chain id 'A', atom 1444 OXT) with
> chain starting with residue LYS284 (chain id 'B', atom 1445 N)? [n/y]
> y
> Merge chain ending with residue LEU427 (chain id 'B', atom 2888 OXT) with
> chain starting with residue LYS567 (chain id 'C', atom 2889 N)? [n/y]
> n
> Merge chain ending with residue LEU710 (chain id 'C', atom 4332 OXT) with
> chain starting with residue CYS145 (chain id 'R', atom 1 N)? [n/y]
> y
> Merge chain ending with residue CYS283 (chain id 'R', atom 1400 OXT) with
> chain starting with residue CYS428 (chain id 'S', atom 1401 N)? [n/y]
> n
> Merge chain ending with residue CYS566 (chain id 'S', atom 2800 OXT) with
> chain starting with residue CYS711 (chain id 'T', atom 2801 N)? [n/y]
> y
> 
> 
> 
> *************************
> 
> After ABC , I include a 'TER', then start chain RST, and make 'chainsep ter'
> 
> 2.    newpdb2gmx -f chainABCRSTter.pdb -p dimertop.top -o dimerpdb.pdb 
> -chainsep ter -ignh
> Program newpdb2gmx, VERSION 4.5.1
> Source code file: pdb2gmx.c, line: 655
> 
> Fatal error:
> Atom OXT in residue LEU 427 was not found in rtp entry LEU with 19 atoms
> while sorting atoms.
> 
> 
> The residue are not in sequential Order , but i dont think that is the 
> problem here.
> 
> Thank you.
> 
> Best,
> nahren
> 
> 
> --- On *Fri, 9/3/10, Justin A. Lemkul /<jalemkul at vt.edu>/* wrote:
> 
> 
>     From: Justin A. Lemkul <jalemkul at vt.edu>
>     Subject: Re: [gmx-users] intermolecular distance restrains
>     To: "Gromacs Users' List" <gmx-users at gromacs.org>
>     Date: Friday, September 3, 2010, 3:18 AM
> 
> 
> 
>     nahren manuel wrote:
>      >
>      > Dear Gromacs Users,
>      >
>      > The problem actually is mine is a hexamer, ARBSCT  (chains). I
>     want RST to be merged into a single molecular topology. I am either
>     able to merge RS or ST or RT but not the trimer as such.
>      >
> 
>     How is the .pdb set up?  Does it have both chain ID's and TER
>     delimiters?  What was your pdb2gmx command line?
> 
>     -Justin
> 
>      > I am able to do with -merge in the previous (ver 4.0.7 of ) pdb2gmx.
>      >
>      > Best,
>      > nahren
>      >
>      > --- On *Thu, 9/2/10, Justin A. Lemkul /<jalemkul at vt.edu
>     </mc/compose?to=jalemkul at vt.edu>>/* wrote:
>      >
>      >
>      >     From: Justin A. Lemkul <jalemkul at vt.edu
>     </mc/compose?to=jalemkul at vt.edu>>
>      >     Subject: Re: [gmx-users] intermolecular distance restrains
>      >     To: "Discussion list for GROMACS users"
>     <gmx-users at gromacs.org </mc/compose?to=gmx-users at gromacs.org>>
>      >     Date: Thursday, September 2, 2010, 8:09 PM
>      >
>      >
>      >
>      >     nahren manuel wrote:
>      >      > Dear Gromacs Users,
>      >      >
>      >      > I am presently using gromacs4.5 beta(since I want implicit
>      >     solvent). I
>      >
>      >     No need to use a beta version, the official 4.5 has been
>     released.
>      >
>      >      > wish to apply intermolecular distance restraints.
>      >      > To my surprise there is no merge option in pdb2gmx (although
>      >     pdb2gnx -h, says it has). So is there a new alternative to create
>      >     intermolecular distance restrains.
>      >      >
>      >
>      >     Use pdb2gmx -chainsep.
>      >
>      >     -Justin
>      >
>      >      > Best,
>      >      > nahren
>      >      >
>      >      >
>      >
>      >     -- ========================================
>      >
>      >     Justin A. Lemkul
>      >     Ph.D. Candidate
>      >     ICTAS Doctoral Scholar
>      >     MILES-IGERT Trainee
>      >     Department of Biochemistry
>      >     Virginia Tech
>      >     Blacksburg, VA
>      >     jalemkul[at]vt.edu | (540) 231-9080
>      >     http://www.bevanlab.biochem.vt.edu/Pages/Personal/justin
>      >
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>     -- ========================================
> 
>     Justin A. Lemkul
>     Ph.D. Candidate
>     ICTAS Doctoral Scholar
>     MILES-IGERT Trainee
>     Department of Biochemistry
>     Virginia Tech
>     Blacksburg, VA
>     jalemkul[at]vt.edu | (540) 231-9080
>     http://www.bevanlab.biochem.vt.edu/Pages/Personal/justin
> 
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> 

-- 
========================================

Justin A. Lemkul
Ph.D. Candidate
ICTAS Doctoral Scholar
MILES-IGERT Trainee
Department of Biochemistry
Virginia Tech
Blacksburg, VA
jalemkul[at]vt.edu | (540) 231-9080
http://www.bevanlab.biochem.vt.edu/Pages/Personal/justin

========================================



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