[gmx-users] invalid pairstype 180

Monoj Mon Kalita mon.123chem at gmail.com
Thu Mar 28 18:14:33 CET 2013


Dear GMX-Users

I have a problem while trying to insert a drug molecule into my simulation.
I have the topology file generated from the ATB-server. And accordingly I
have edited the aminoacid.rtp & ffbonded.itp file. I have transcribed the
forcefield parameters into GROMOS96 format. here is my .itp file for that
molecule. My problem is that after doing all the things when i tried to do
sd minimization then i got the error message like

*Program grompp, VERSION 4.5.5*
*Source code file:
/home/abuild/rpmbuild/BUILD/gromacs-4.5.5/src/kernel/topdirs.c, line: 107*
*
*
*Fatal error:*
*Invalid pairs type 180*
*For more information and tips for troubleshooting, please check the GROMACS
*
*website at http://www.gromacs.org/Documentation/Errors*

What may be the reason ? And when i studied through the .itp file then i
have found the 1-4 interactions in the [ pairs ] section followed by the
excluded 1-4 interactions. Now, my other question is that should I address
these 1-4 interactions in the ffnonbonded.itp file ! Looking forward for
kind response.

[ moleculetype ]
; Name   nrexcl
_NW5     3
[ atoms ]
;  nr  type  resnr  resid  atom  cgnr  charge    mass    total_charge
    1   CH3    1    _NW5    C14    1   -0.000  15.0350      ;  0.000
    2     C    1    _NW5     C8    2   -0.217  12.0110
    3    HC    1    _NW5     H1    2    0.138   1.0080
    4     C    1    _NW5    C11    2   -0.111  12.0110
    5     C    1    _NW5    C15    2    0.717  12.0110
    6     O    1    _NW5     O1    2   -0.580  15.9994
    7     N    1    _NW5     N2    2   -0.663  14.0067
    8     H    1    _NW5     H8    2    0.372   1.0080
    9     C    1    _NW5    C16    2    0.785  12.0110
   10    NT    1    _NW5     N5    2   -0.939  14.0067
   11     H    1    _NW5     H9    2    0.398   1.0080
   12     H    1    _NW5    H10    2    0.398   1.0080
   13    NR    1    _NW5     N1    2   -0.841  14.0067
   14     H    1    _NW5     H7    2    0.347   1.0080
   15     C    1    _NW5     C1    2    0.040  12.0110
   16     C    1    _NW5     C2    2    0.040  12.0110
   17     C    1    _NW5     C3    2   -0.151  12.0110
   18     C    1    _NW5     C5    2    0.150  12.0110
   19     C    1    _NW5    C13    2    0.149  12.0110
   20    HC    1    _NW5    H14    2    0.099   1.0080
   21    NR    1    _NW5     N3    2   -0.567  14.0067
   22    NR    1    _NW5     N4    2    0.436  14.0067      ;  0.000
   23     C    1    _NW5    C10    3   -0.154  12.0110
   24    HC    1    _NW5     H6    3    0.154   1.0080      ;  0.000
   25     C    1    _NW5     C6    4   -0.154  12.0110
   26    HC    1    _NW5     H3    4    0.154   1.0080      ;  0.000
   27     C    1    _NW5     C4    5   -0.154  12.0110
   28    HC    1    _NW5     H2    5    0.154   1.0080      ;  0.000
   29     C    1    _NW5     C9    6   -0.152  12.0110
   30    HC    1    _NW5     H5    6    0.152   1.0080      ;  0.000
   31     C    1    _NW5     C7    7   -0.154  12.0110
   32    HC    1    _NW5     H4    7    0.154   1.0080      ;  0.000
   33     C    1    _NW5    C12    8   -0.200  12.0110
   34    HC    1    _NW5    H15    8    0.200   1.0080      ;  0.000
; total charge of the molecule:   0.000
[ bonds ]
;  ai   aj  funct   c0         c1
    1   22    2   0.1470   8.7100e+06
    2    3    2   0.1090   1.2300e+07
    2    4    2   0.1390   8.6600e+06
    2   18    2   0.1435   6.1000e+06
    4    5    2   0.1520   5.4300e+06
    4   23    2   0.1435   6.1000e+06
    5    6    2   0.1230   1.6600e+07
    5    7    2   0.1380   1.1000e+07
    7    8    2   0.1000   1.8700e+07
    7    9    2   0.1400   8.5400e+06
    9   10    2   0.1400   8.5400e+06
    9   13    2   0.1320   1.2000e+07
   10   11    2   0.1000   1.8700e+07
   10   12    2   0.1000   1.8700e+07
   13   14    2   0.1000   1.8700e+07
   15   16    2   0.1435   6.1000e+06
   15   17    2   0.1480   5.7300e+06
   15   27    2   0.1390   8.6600e+06
   16   18    2   0.1435   6.1000e+06
   16   25    2   0.1435   6.1000e+06
   17   19    2   0.1390   8.6600e+06
   17   33    2   0.1390   8.6600e+06
   18   31    2   0.1435   6.1000e+06
   19   20    2   0.1090   1.2300e+07
   19   21    2   0.1330   1.0600e+07
   21   22    2   0.1360   4.7700e+06
   22   33    2   0.1350   1.0300e+07
   23   24    2   0.1090   1.2300e+07
   23   25    2   0.1390   1.0800e+07
   25   26    2   0.1090   1.2300e+07
   27   28    2   0.1090   1.2300e+07
   27   29    2   0.1435   6.1000e+06
   29   30    2   0.1090   1.2300e+07
   29   31    2   0.1390   1.0800e+07
   31   32    2   0.1090   1.2300e+07
   33   34    2   0.1090   1.2300e+07
[ pairs ]
;  ai   aj  funct  ;  all 1-4 pairs but the ones excluded in GROMOS itp
    2    6    1
    2    7    1
    4    8    1
    4    9    1
    5   10    1
    5   13    1
    6    8    1
    6    9    1
    6   23    1
    7   11    1
    7   12    1
    7   14    1
    7   23    1
    8   10    1
    8   13    1
   10   14    1
   11   13    1
   12   13    1
   16   19    1
   16   33    1
   19   27    1
   27   33    1
[ angles ]
;  ai   aj   ak  funct   angle     fc
    3    2    4    2    120.00   390.00
    3    2   18    2    120.00   390.00
    4    2   18    2    120.00   560.00
    2    4    5    2    120.00   560.00
    2    4   23    2    120.00   560.00
    5    4   23    2    125.00   750.00
    4    5    6    2    121.00   685.00
    4    5    7    2    115.00   610.00
    6    5    7    2    124.00   730.00
    5    7    8    2    116.00   465.00
    5    7    9    2    125.00   750.00
    8    7    9    2    115.00   460.00
    7    9   10    2    110.00  1280.00
    7    9   13    2    120.00   560.00
   10    9   13    2    125.00   750.00
    9   10   11    2    116.00   465.00
    9   10   12    2    115.00   460.00
   11   10   12    2    109.50   285.00
    9   13   14    2    109.50   285.00
   16   15   17    2    120.00   560.00
   16   15   27    2    120.00   560.00
   17   15   27    2    120.00   560.00
   15   16   18    2    120.00   560.00
   15   16   25    2    125.00   750.00
   18   16   25    2    120.00   560.00
   15   17   19    2    132.00   760.00
   15   17   33    2    126.00   640.00
   19   17   33    2    105.00  1320.00
    2   18   16    2    120.00   560.00
    2   18   31    2    120.00   560.00
   16   18   31    2    120.00   560.00
   17   19   20    2    126.00   575.00
   17   19   21    2    111.00   530.00
   20   19   21    2    120.00   505.00
   19   21   22    2    106.00  1690.00
    1   22   21    2    119.00  1210.00
    1   22   33    2    125.00   750.00
   21   22   33    2    112.00  1400.00
    4   23   24    2    120.00   390.00
    4   23   25    2    120.00   560.00
   24   23   25    2    120.00   390.00
   16   25   23    2    120.00   560.00
   16   25   26    2    120.00   390.00
   23   25   26    2    120.00   390.00
   15   27   28    2    120.00   390.00
   15   27   29    2    120.00   560.00
   28   27   29    2    120.00   390.00
   27   29   30    2    120.00   390.00
   27   29   31    2    120.00   560.00
   30   29   31    2    120.00   390.00
   18   31   29    2    120.00   560.00
   18   31   32    2    120.00   390.00
   29   31   32    2    120.00   390.00
   17   33   22    2    108.00   465.00
   17   33   34    2    131.00   927.00
   22   33   34    2    121.40   690.00
[ dihedrals ]
; GROMOS improper dihedrals
;  ai   aj   ak   al  funct   angle     fc
   15   27   29   31    2      0.00   167.36
   27   29   31   18    2      0.00   167.36
   29   31   18   16    2      0.00   167.36
   31   18   16   15    2      0.00   167.36
   18   16   15   27    2      0.00   167.36
   16   15   27   29    2      0.00   167.36
   17   19   21   22    2      0.00   167.36
   19   21   22   33    2      0.00   167.36
   21   22   33   17    2      0.00   167.36
   22   33   17   19    2      0.00   167.36
   33   17   19   21    2      0.00   167.36
   16   25   23    4    2      0.00   167.36
   25   23    4    2    2      0.00   167.36
   23    4    2   18    2      0.00   167.36
    4    2   18   16    2      0.00   167.36
    2   18   16   25    2      0.00   167.36
   18   16   25   23    2      0.00   167.36
   15   16   17   27    2      0.00   167.36
   16   15   18   25    2      0.00   167.36
   17   15   19   33    2      0.00   167.36
   27   15   28   29    2      0.00   167.36
   18    2   16   31    2      0.00   167.36
   25   16   23   26    2      0.00   167.36
   31   18   29   32    2      0.00   167.36
    2    3    4   18    2      0.00   167.36
   29   27   30   31    2      0.00   167.36
   23    4   24   25    2      0.00   167.36
    4    2    5   23    2      0.00   167.36
   33   17   22   34    2      0.00   167.36
   19   17   20   21    2      0.00   167.36
    5    4    6    7    2      0.00   167.36
    9    7   10   13    2      0.00   167.36
    7    5    8    9    2      0.00   167.36
   22    1   21   33    2      0.00   167.36
[ dihedrals ]
;  ai   aj   ak   al  funct    ph0      cp     mult
    2    4    5    7    1    180.00    33.50    2
    4    5    7    9    1    180.00    33.50    2
    5    7    9   13    1    180.00    33.50    2
   13    9   10   11    1    180.00    33.50    2
    7    9   13   14    1    180.00    33.50    2
   16   15   17   33    1    180.00     1.53    2
[ exclusions ]
;  ai   aj  funct  ;  GROMOS 1-4 exclusions
    1   17
    1   19
    1   34
    2   15
    2   24
    2   25
    2   29
    2   32
    3    5
    3   16
    3   23
    3   31
    4   16
    4   26
    4   31
    5   18
    5   24
    5   25
   15   20
   15   21
   15   22
   15   23
   15   26
   15   30
   15   31
   15   34
   16   24
   16   28
   16   29
   16   32
   17   18
   17   25
   17   28
   17   29
   18   23
   18   26
   18   27
   18   30
   19   34
   20   22
   20   33
   21   34
   24   26
   25   27
   25   31
   27   32
   28   30
   28   31
   30   32


-- 


With Regards
Monoj Mon Kalita
Institute of Biophotonics<http://www.ym.edu.tw/biophotonics/eng_version/home.htm>
Fischer's Lab <http://www.ym.edu.tw/%7Ewfischer/group_mon.htm>
National Yang-Ming University<http://nymu-e.web.ym.edu.tw/front/bin/home.phtml>
Taipei, Taiwan
mon.123chem at gmail.com



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