[gmx-users] Urea induced denaturation

[Douglas Grahame]

Hi everyone, just wondering if anyone can suggest some papers or links to
sources for urea induced denaturation. I'm trying to look at protein
stability of various mutants but simulated annealing and simulations at
constant temperature up to 500 ps  haven't shown or reflected or wet lab
data. Hoping to examine urea denaturation to assess the strength of a
beta-barrel hydrophobic core. Any suggestions or hints in the right
direction would be great! Thanks everyone,

 

-Douglas Grahame

BSc. MSc. PhD. Candidate

dgrahame at uoguelph.ca

 



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