[gmx-users] question

Tsjerk Wassenaar tsjerkw at gmail.com
Sat May 16 21:22:29 CEST 2015


Hi Andrew,

I guess you want a link between the chains. In that case you'll need to use
the option -merge.

Cheers,

Tsjerk

On Sat, May 16, 2015 at 8:46 PM, Andrew Bostick <andrew.bostick1 at gmail.com>
wrote:

> After using pdb2gmx, my terminal output is as follows:
>
> Using the Gromos43a1 force field in directory gromos43a1.ff
>
> Opening force field file
> /usr/local/gromacs/share/gromacs/top/gromos43a1.ff/watermodels.dat
>
> Select the Water Model:
>  1: SPC    simple point charge, recommended
>  2: SPC/E  extended simple point charge
>  3: None
> 1
> Opening force field file
> /usr/local/gromacs/share/gromacs/top/gromos43a1.ff/aminoacids.r2b
> Reading be_near.pdb...
> Read 2585 atoms
> Analyzing pdb file
> Splitting PDB chains based on TER records or changing chain id.
> There are 2 chains and 0 blocks of water and 551 residues with 2585 atoms
>
>   chain  #res #atoms
>   1 'B'   215   1710
>   2 'E'   117    875
>
> All occupancies are one
> Opening force field file
> /usr/local/gromacs/share/gromacs/top/gromos43a1.ff/atomtypes.atp
> Atomtype 1
> Reading residue database... (gromos43a1)
> Opening force field file
> /usr/local/gromacs/share/gromacs/top/gromos43a1.ff/aminoacids.rtp
> Residue 98
> Sorting it all out...
> Opening force field file
> /usr/local/gromacs/share/gromacs/top/gromos43a1.ff/aminoacids.hdb
> Opening force field file
> /usr/local/gromacs/share/gromacs/top/gromos43a1.ff/aminoacids.n.tdb
> Opening force field file
> /usr/local/gromacs/share/gromacs/top/gromos43a1.ff/aminoacids.c.tdb
>
> Back Off! I just backed up topol.top to ./#topol.top.1#
> Processing chain 1 'B' (1710 atoms, 215 residues)
> There are 322 donors and 327 acceptors
> There are 518 hydrogen bonds
> Will use HISE for residue 276
> Will use HISE for residue 301
> Will use HISE for residue 420
> Will use HISE for residue 424
> Will use HISE for residue 426
> Will use HISE for residue 427
> Will use HISE for residue 434
> Identified residue PRO220 as a starting terminus.
> Identified residue HIS434 as a ending terminus.
> 9 out of 9 lines of specbond.dat converted successfully
> Special Atom Distance matrix:
>                   CYS221  CYS223  GLU227  LYS237  LYS239  LYS249  CYS252
>                     SG13    SG27    CD53   NZ134   NZ150   NZ226   SG248
>   CYS223    SG27   0.510
>   GLU227    CD53   1.444   1.406
>   LYS237   NZ134   3.625   3.530   3.793
>   LYS239   NZ150   4.148   4.082   4.362   0.606
>   LYS249   NZ226   3.633   3.625   3.499   1.129   1.354
>   CYS252   SG248   2.066   2.153   2.028   2.061   2.536   1.649
>   LYS259   NZ298   3.093   2.923   1.874   3.475   4.009   2.975   2.346
>   GLU263   CD328   3.069   3.158   2.308   2.930   3.325   2.019   1.474
>   GLU274   CD425   2.622   2.907   2.615   2.866   3.168   2.174   1.221
>   HIS276  NE2444   3.347   3.624   3.268   3.015   3.203   2.171   1.766
>   GLU284   CD506   2.957   2.948   2.046   2.858   3.320   2.086   1.525
>   GLU285   CD515   3.076   2.982   2.460   2.030   2.510   1.410   1.396
>   MET300   SD635   3.692   3.889   3.960   2.150   2.131   1.664   1.995
>   HIS301  NE2646   3.819   3.906   4.086   1.358   1.240   1.199   2.064
>   LYS308   NZ706   3.118   3.374   3.601   2.409   2.513   2.107   1.798
>   GLU309   CD713   2.138   2.447   2.779   2.674   2.972   2.464   1.384
>   LYS311   NZ735   1.714   2.056   2.304   2.882   3.256   2.625   1.242
>   CYS312   SG743   2.082   2.214   2.050   2.199   2.647   1.726   0.203
>   GLU324   CD828   1.606   1.936   1.980   2.934   3.347   2.588   1.074
>   LYS325   NZ839   1.399   1.432   1.731   2.303   2.828   2.237   0.780
>   LYS329   NZ869   3.010   3.072   3.668   1.475   1.628   1.938   1.912
>   LYS331   NZ885   2.095   2.230   3.066   2.322   2.639   2.642   1.806
>   LYS333   NZ898   3.201   3.360   4.217   2.653   2.718   3.098   2.748
>   LYS346  NZ1001   6.138   5.902   6.647   3.467   3.269   4.536   5.334
>   GLU347  CD1008   5.388   5.108   5.909   3.153   3.129   4.262   4.809
>   MET349  SD1026   6.176   5.912   6.574   3.426   3.260   4.462   5.315
>   LYS351  NZ1041   5.381   5.050   5.656   3.045   3.104   4.056   4.684
>   LYS353  NZ1058   5.609   5.319   5.671   2.665   2.624   3.502   4.490
>   CYS358  SG1094   4.478   4.345   4.996   1.599   1.405   2.677   3.416
>   MET359  SD1099   4.296   4.129   4.999   2.193   2.178   3.298   3.666
>   GLU366  CD1159   2.694   2.640   3.428   1.549   1.871   2.269   2.015
>   GLU371  CD1198   4.089   3.993   4.364   0.608   0.350   1.598   2.618
>   GLU380  CD1269   4.929   4.724   4.913   1.570   1.489   2.243   3.461
>   LYS383  NZ1300   4.109   3.853   4.198   1.347   1.602   2.244   2.969
>   MET389  SD1346   2.803   2.714   3.788   2.344   2.614   3.148   2.730
>   LYS400  NZ1437   4.512   4.242   4.802   1.907   2.005   2.956   3.609
>   LYS405  NZ1478   6.045   5.762   6.299   3.180   3.053   4.149   5.075
>   GLU409  CD1513   6.268   6.022   6.532   3.171   2.938   4.100   5.161
>   CYS416  SG1565   4.478   4.352   4.951   1.453   1.218   2.512   3.327
>   HIS420 NE21594   3.511   3.512   4.225   1.534   1.535   2.311   2.546
>   GLU421  CD1601   3.375   3.423   4.043   1.485   1.504   2.067   2.269
>   HIS424 NE21625   4.712   4.746   5.439   2.326   1.981   3.030   3.638
>   HIS426 NE21643   3.940   4.027   4.508   1.663   1.449   2.036   2.585
>   HIS427 NE21653   4.616   4.578   5.023   1.368   0.849   2.110   3.164
>   GLU429  CD1667   4.903   4.846   5.320   1.621   1.099   2.406   3.492
>   LYS430  NZ1678   4.918   4.813   5.540   2.168   1.875   3.185   3.923
>   HIS434 NE21708   6.201   5.991   6.588   3.125   2.832   4.102   5.125
>                   LYS259  GLU263  GLU274  HIS276  GLU284  GLU285  MET300
>                    NZ298   CD328   CD425  NE2444   CD506   CD515   SD635
>   GLU263   CD328   1.809
>   GLU274   CD425   3.077   1.556
>   HIS276  NE2444   3.462   1.729   0.726
>   GLU284   CD506   1.216   0.623   2.004   2.284
>   GLU285   CD515   1.567   1.273   2.237   2.490   0.927
>   MET300   SD635   4.078   2.600   1.658   1.426   2.974   2.701
>   HIS301  NE2646   4.001   2.813   2.234   2.142   3.030   2.490   0.899
>   LYS308   NZ706   4.084   2.694   1.401   1.456   3.049   2.872   0.797
>   GLU309   CD713   3.650   2.528   1.205   1.714   2.786   2.745   1.717
>   LYS311   NZ735   3.330   2.338   1.160   1.814   2.552   2.629   2.116
>   CYS312   SG743   2.427   1.421   1.023   1.594   1.548   1.514   1.925
>   GLU324   CD828   2.999   2.045   1.048   1.762   2.242   2.411   2.262
>   LYS325   NZ839   2.514   2.115   1.765   2.412   2.029   1.880   2.529
>   LYS329   NZ869   4.051   3.203   2.396   2.655   3.296   2.760   1.668
>   LYS331   NZ885   3.945   3.254   2.281   2.774   3.320   2.998   2.270
>   LYS333   NZ898   4.995   4.098   2.944   3.225   4.251   3.851   2.308
>   LYS346  NZ1001   6.400   6.347   6.200   6.373   6.158   5.261   5.202
>   GLU347  CD1008   5.766   5.890   5.783   6.057   5.643   4.774   5.018
>   MET349  SD1026   6.193   6.244   6.231   6.404   6.017   5.105   5.293
>   LYS351  NZ1041   5.240   5.580   5.746   6.019   5.256   4.369   5.121
>   LYS353  NZ1058   4.931   5.138   5.471   5.625   4.845   3.924   4.738
>   CYS358  SG1094   4.899   4.495   4.174   4.335   4.411   3.577   3.168
>   MET359  SD1099   5.149   4.909   4.494   4.771   4.782   3.993   3.681
>   GLU366  CD1159   3.881   3.411   2.813   3.212   3.360   2.769   2.425
>   GLU371  CD1198   4.066   3.505   3.339   3.434   3.456   2.623   2.371
>   GLU380  CD1269   4.133   4.003   4.321   4.393   3.801   2.880   3.534
>   LYS383  NZ1300   3.671   3.761   4.007   4.247   3.482   2.574   3.495
>   MET389  SD1346   4.476   4.177   3.503   3.958   4.091   3.539   3.191
>   LYS400  NZ1437   4.453   4.550   4.625   4.881   4.289   3.398   3.977
>   LYS405  NZ1478   5.753   5.886   6.027   6.189   5.627   4.705   5.160
>   GLU409  CD1513   5.962   5.940   6.031   6.131   5.731   4.806   5.030
>   CYS416  SG1565   4.805   4.365   4.068   4.206   4.291   3.452   3.034
>   HIS420 NE21594   4.531   3.818   3.101   3.320   3.860   3.218   2.189
>   GLU421  CD1601   4.359   3.508   2.719   2.912   3.603   3.017   1.778
>   HIS424 NE21625   5.639   4.755   3.960   3.993   4.872   4.207   2.623
>   HIS426 NE21643   4.679   3.621   2.804   2.814   3.800   3.227   1.465
>   HIS427 NE21653   4.828   4.061   3.665   3.658   4.108   3.333   2.370
>   GLU429  CD1667   5.089   4.379   4.014   4.003   4.406   3.606   2.706
>   LYS430  NZ1678   5.524   5.033   4.580   4.705   4.991   4.178   3.438
>   HIS434 NE21708   6.168   6.003   5.930   6.020   5.845   4.932   4.831
>                   HIS301  LYS308  GLU309  LYS311  CYS312  GLU324  LYS325
>                   NE2646   NZ706   CD713   NZ735   SG743   CD828   NZ839
>   LYS308   NZ706   1.405
>   GLU309   CD713   2.128   1.018
>   LYS311   NZ735   2.500   1.486   0.516
>   CYS312   SG743   2.082   1.700   1.274   1.122
>   GLU324   CD828   2.633   1.722   0.850   0.381   0.940
>   LYS325   NZ839   2.523   2.149   1.441   1.188   0.879   1.072
>   LYS329   NZ869   1.295   1.463   1.656   2.013   1.969   2.242   1.938
>   LYS331   NZ885   2.234   1.693   1.201   1.399   1.836   1.677   1.465
>   LYS333   NZ898   2.250   1.810   1.864   2.266   2.754   2.611   2.587
>   LYS346  NZ1001   4.349   5.365   5.612   5.868   5.490   6.016   5.229
>   GLU347  CD1008   4.197   5.078   5.154   5.342   4.979   5.467   4.597
>   MET349  SD1026   4.417   5.495   5.726   5.952   5.481   6.068   5.233
>   LYS351  NZ1041   4.276   5.254   5.296   5.422   4.871   5.478   4.525
>   LYS353  NZ1058   3.860   5.041   5.242   5.392   4.668   5.416   4.530
>   CYS358  SG1094   2.341   3.313   3.611   3.903   3.550   4.064   3.407
>   MET359  SD1099   2.954   3.642   3.741   3.992   3.806   4.176   3.461
>   GLU366  CD1159   1.980   2.163   2.012   2.214   2.130   2.394   1.764
>   GLU371  CD1198   1.492   2.668   3.044   3.315   2.745   3.415   2.816
>   GLU380  CD1269   2.675   3.931   4.240   4.418   3.618   4.431   3.674
>   LYS383  NZ1300   2.693   3.690   3.764   3.874   3.153   3.883   2.987
>   MET389  SD1346   2.796   2.815   2.526   2.687   2.839   2.900   2.285
>   LYS400  NZ1437   3.143   4.116   4.199   4.350   3.789   4.414   3.516
>   LYS405  NZ1478   4.270   5.414   5.637   5.833   5.248   5.910   5.042
>   GLU409  CD1513   4.133   5.341   5.665   5.902   5.322   5.995   5.194
>   CYS416  SG1565   2.190   3.220   3.553   3.849   3.458   4.003   3.361
>   HIS420 NE21594   1.627   2.090   2.338   2.691   2.629   2.925   2.506
>   GLU421  CD1601   1.293   1.674   1.999   2.383   2.329   2.621   2.313
>   HIS424 NE21625   2.070   2.709   3.266   3.706   3.693   3.975   3.711
>   HIS426 NE21643   0.958   1.611   2.271   2.717   2.614   2.953   2.807
>   HIS427 NE21653   1.524   2.714   3.286   3.652   3.255   3.818   3.385
>   GLU429  CD1667   1.866   3.054   3.621   3.986   3.588   4.154   3.689
>   LYS430  NZ1678   2.657   3.571   3.939   4.278   4.040   4.481   3.904
>   HIS434 NE21708   3.951   5.112   5.476   5.753   5.274   5.885   5.144
>                   LYS329  LYS331  LYS333  LYS346  GLU347  MET349  LYS351
>                    NZ869   NZ885   NZ898  NZ1001  CD1008  SD1026  NZ1041
>   LYS331   NZ885   1.101
>   LYS333   NZ898   1.207   1.167
>   LYS346  NZ1001   3.996   4.683   4.452
>   GLU347  CD1008   3.640   4.154   4.117   0.988
>   MET349  SD1026   4.140   4.838   4.717   0.545   1.030
>   LYS351  NZ1041   3.884   4.412   4.594   1.612   1.026   1.259
>   LYS353  NZ1058   3.843   4.571   4.759   2.042   1.924   1.601   1.192
>   CYS358  SG1094   1.978   2.819   2.649   2.059   1.911   2.197   2.256
>   MET359  SD1099   2.194   2.728   2.566   1.985   1.555   2.220   2.164
>   GLU366  CD1159   0.825   1.054   1.516   3.686   3.155   3.806   3.379
>   GLU371  CD1198   1.601   2.573   2.657   2.983   2.796   2.982   2.799
>   GLU380  CD1269   2.945   3.793   4.017   2.762   2.645   2.512   2.198
>   LYS383  NZ1300   2.528   3.153   3.556   2.750   2.275   2.550   1.848
>   MET389  SD1346   1.547   1.340   1.592   3.623   3.002   3.814   3.403
>   LYS400  NZ1437   2.781   3.390   3.607   1.951   1.414   1.786   1.150
>   LYS405  NZ1478   4.107   4.829   4.837   1.184   1.338   0.674   1.000
>   GLU409  CD1513   4.093   4.909   4.815   1.177   1.661   0.802   1.534
>   CYS416  SG1565   1.927   2.819   2.667   2.177   2.060   2.286   2.335
>   HIS420 NE21594   0.711   1.566   1.312   3.360   3.064   3.553   3.432
>   GLU421  CD1601   0.388   1.411   1.214   3.733   3.450   3.904   3.757
>   HIS424 NE21625   1.786   2.662   1.894   3.184   3.253   3.488   3.804
>   HIS426 NE21643   0.973   1.994   1.577   3.901   3.789   4.079   4.092
>   HIS427 NE21653   1.753   2.827   2.550   2.915   2.959   3.027   3.178
>   GLU429  CD1667   2.057   3.110   2.783   2.644   2.780   2.768   3.034
>   LYS430  NZ1678   2.286   3.119   2.708   1.897   1.974   2.177   2.546
>   HIS434 NE21708   3.851   4.685   4.456   0.845   1.560   0.810   1.813
>                   LYS353  CYS358  MET359  GLU366  GLU371  GLU380  LYS383
>                   NZ1058  SG1094  SD1099  CD1159  CD1198  CD1269  NZ1300
>   CYS358  SG1094   2.244
>   MET359  SD1099   2.604   0.905
>   GLU366  CD1159   3.535   1.841   1.785
>   GLU371  CD1198   2.413   1.100   1.851   1.705
>   GLU380  CD1269   1.322   1.830   2.515   2.850   1.397
>   LYS383  NZ1300   1.544   1.639   2.011   2.176   1.369   1.032
>   MET389  SD1346   3.838   2.124   1.663   0.884   2.385   3.420   2.646
>   LYS400  NZ1437   1.284   1.335   1.480   2.343   1.688   1.432   0.862
>   LYS405  NZ1478   0.964   2.237   2.415   3.777   2.797   2.047   2.173
>   GLU409  CD1513   1.195   2.173   2.501   3.871   2.718   2.010   2.354
>   CYS416  SG1565   2.221   0.203   1.099   1.851   0.923   1.697   1.579
>   HIS420 NE21594   3.473   1.394   1.570   0.912   1.399   2.731   2.344
>   GLU421  CD1601   3.709   1.716   1.982   0.984   1.460   2.842   2.503
>   HIS424 NE21625   3.755   1.589   1.926   2.161   1.912   3.100   3.059
>   HIS426 NE21643   3.879   1.913   2.390   1.688   1.533   2.902   2.815
>   HIS427 NE21653   2.809   1.097   1.918   2.071   0.840   1.918   2.104
>   GLU429  CD1667   2.661   1.018   1.865   2.308   1.039   1.889   2.152
>   LYS430  NZ1678   2.612   0.647   1.011   2.234   1.628   2.338   2.262
>   HIS434 NE21708   1.689   1.882   2.182   3.675   2.603   2.229   2.513
>                   MET389  LYS400  LYS405  GLU409  CYS416  HIS420  GLU421
>                   SD1346  NZ1437  NZ1478  CD1513  SG1565 NE21594  CD1601
>   LYS400  NZ1437   2.562
>   LYS405  NZ1478   3.905   1.538
>   GLU409  CD1513   4.057   1.793   0.570
>   CYS416  SG1565   2.214   1.372   2.280   2.191
>   HIS420 NE21594   1.384   2.388   3.598   3.564   1.384
>   GLU421  CD1601   1.606   2.671   3.908   3.857   1.668   0.423
>   HIS424 NE21625   2.412   2.916   3.666   3.460   1.579   1.256   1.402
>   HIS426 NE21643   2.303   3.009   4.078   3.928   1.817   0.979   0.717
>   HIS427 NE21653   2.637   2.181   2.979   2.764   0.929   1.383   1.457
>   GLU429  CD1667   2.800   2.118   2.750   2.495   0.864   1.609   1.743
>   LYS430  NZ1678   2.370   1.834   2.385   2.233   0.757   1.613   1.958
>   HIS434 NE21708   3.809   1.886   1.025   0.634   1.926   3.259   3.574
>                   HIS424  HIS426  HIS427  GLU429  LYS430
>                  NE21625 NE21643 NE21653  CD1667  NZ1678
>   HIS426 NE21643   1.188
>   HIS427 NE21653   1.268   1.228
>   GLU429  CD1667   1.310   1.529   0.350
>   LYS430  NZ1678   1.322   2.047   1.283   1.096
>   HIS434 NE21708   2.998   3.617   2.487   2.184   1.778
> Linking CYS-252 SG-248 and CYS-312 SG-743...
> Linking CYS-358 SG-1094 and CYS-416 SG-1565...
> Start terminus PRO-220: PRO-NH2+
> End terminus HIS-434: COO-
> Checking for duplicate atoms....
> Now there are 215 residues with 2170 atoms
> Chain time...
> Making bonds...
> Number of bonds was 2225, now 2221
> Generating angles, dihedrals and pairs...
> Before cleaning: 3579 pairs
> Before cleaning: 4281 dihedrals
> Making cmap torsions...There are 1188 dihedrals, 1103 impropers, 3254
> angles
>           3579 pairs,     2221 bonds and     0 virtual sites
> Total mass 24305.633 a.m.u.
> Total charge -5.000 e
> Writing topology
> Processing chain 2 'E' (875 atoms, 117 residues)
> There are 186 donors and 177 acceptors
> There are 298 hydrogen bonds
> Will use HISE for residue 506
> Will use HISE for residue 546
> Identified residue GLY435 as a starting terminus.
> Identified residue LYS551 as a ending terminus.
> 9 out of 9 lines of specbond.dat converted successfully
> Special Atom Distance matrix:
>                   GLU463  GLU470  LYS499  HIS506  GLU520  GLU535  LYS540
>                    CD205   CD249   NZ469  NE2531   CD628   CD746   NZ789
>   GLU470   CD249   1.118
>   LYS499   NZ469   1.596   1.306
>   HIS506  NE2531   2.138   1.493   1.065
>   GLU520   CD628   2.260   3.211   3.593   3.893
>   GLU535   CD746   3.466   3.161   2.570   1.821   4.426
>   LYS540   NZ789   2.821   2.362   2.493   1.589   3.763   1.550
>   HIS546  NE2831   2.133   2.600   2.943   2.795   1.663   3.007   2.204
>   LYS551   NZ873   1.393   2.494   2.682   3.242   1.189   4.082   3.598
>                   HIS546
>                   NE2831
>   LYS551   NZ873   1.997
> Start terminus GLY-435: GLY-NH3+
> End terminus LYS-551: COO-
> Checking for duplicate atoms....
> Now there are 117 residues with 1149 atoms
> Chain time...
> Making bonds...
> Number of bonds was 1176, now 1171
> Generating angles, dihedrals and pairs...
> Before cleaning: 1840 pairs
> Before cleaning: 2295 dihedrals
> Making cmap torsions...There are  570 dihedrals,  643 impropers, 1724
> angles
>           1840 pairs,     1171 bonds and     0 virtual sites
> Total mass 12358.454 a.m.u.
> Total charge -1.000 e
> Writing topology
> Including chain 1 in system: 2170 atoms 215 residues
> Including chain 2 in system: 1149 atoms 117 residues
> Now there are 3319 atoms and 332 residues
> Total mass in system 36664.087 a.m.u.
> Total charge in system -6.000 e
>
> Writing coordinate file...
> --
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-- 
Tsjerk A. Wassenaar, Ph.D.


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