[gmx-users] increasing simulation time via temperature rising

[nazli kashani javid]

Hi all

I'm studying effect of temperature on incredibly stable protein. I've
started simulating at 300K then, 400K and 500K. 30ns simulating takes about
4days for these three temperature in a same system. when I want to run 30ns
simulation at 600K, it will take more than 20 days!!!!

does rising temperature, have any affect on time of simulation?
 is this increasing in time reasonable?

thanks