[gmx-users] replica exchange

[Alexander Kötter]

Dear gromacs users,

is there a way to perform replica exchange in two dimensions? I would like to perform replica exchange umbrella sampling and for each umbrella window I want to have some replicas at higher temperatures (actually REST2). From the manual it doesn't seem as if this was possible, but is there maybe a trick or some other functionality (maybe with plumed, I dont see a way here either however)?

Thanks
Alex