[gmx-users] solvation

Jamie Seyed jamie.seyed at gmail.com
Thu Aug 13 20:39:44 CEST 2009


Hi Justin,
Does it mean each time I can add one until I get the number that I want...??
Many Thanks/Jamie

On Thu, Aug 13, 2009 at 2:13 PM, Justin A. Lemkul <jalemkul at vt.edu> wrote:

>
>
> Jamie Seyed wrote:
>
>> Hi Justin,
>> I made an insert.gro file for 2 water molecules,  and when I used genbox I
>> got a fatal error: more than one residue in insert molecules, program
>> terminated.
>>
>
> Right, like I said before, the insert.gro file should contain coordinates
> for *one* molecule.
>
> I wanted to look at insert.gro, it does not show anything. And when I
>> convert it to pdb I got a warning [file aminoacids.dat, line 1]: Bad box
>> file insert.gro
>>
>
> Well, how did you make this file?  A .gro file has a specific format:
>
> http://manual.gromacs.org/current/online/gro.html
>
> When I looked at the insert.pdb file I found only 1.5 water molecule! Which
>> means 1 water plus a OH. Do you have any idea what should I do or if I am
>> missing some thing? Many Thanks in Advance/Jamie
>>
>>
> I have no idea how you created this broken file, so I can't really comment
> :) The easiest thing to do (I would think) would be to take the first
> molecule of spc216.gro, keep the header lines, set number of atoms = 3 and
> preserve the box information at the bottom.  I've used that before in a few
> cases.
>
> -Justin
>
>  On Thu, Aug 13, 2009 at 1:20 PM, Justin A. Lemkul <jalemkul at vt.edu<mailto:
>> jalemkul at vt.edu>> wrote:
>>
>>
>>
>>    Jamie Seyed wrote:
>>
>>        Hi Justin,
>>        Thanks for your answer,
>>        On Thu, Aug 13, 2009 at 11:42 AM, Justin A. Lemkul
>>        <jalemkul at vt.edu <mailto:jalemkul at vt.edu>
>>         <mailto:jalemkul at vt.edu <mailto:jalemkul at vt.edu>>> wrote:
>>
>>
>>
>>           Jamie Seyed wrote:
>>
>>               Dear all,
>>               I want to know how can I use genbox to fill inside of the
>>        pore
>>               as well as a layer outside. From the "man genbox" page I
>>        try to
>>               use -shell with a negative value (?) but it put waters
>>        far from
>>               the outside of the pore and I think it does not care
>>        about the
>>               sign. It seems strange to me because when I had 10 10 10
>>        in the
>>               last line of my f.gro, by a shell 0.5 or 0.2, I got a
>>        layer of
>>               few molecule around the pore, but when I change it to 1.
>>        1. 1.,
>>               the water molecules generated far away. I appreciate if
>>        someone
>>               tell me (1) how I can add water inside the pore and (2) why
>>
>>
>>           (1) The -vdwd option may help, or even -ci -nmol.  If you have a
>>           pore, wouldn't water diffuse in over time anyway during
>>           equilibration (assuming an otherwise correct setup and realistic
>>           physical model)?
>>
>>         Long time ago I did an experiment on water in confined geometry
>>        and I want to see if the results can obtain from the
>>         simulation... So for using -nmol -ci (at random position), it
>>        says I must use a file like insert.gro would you please explain
>>        me how I can make insert.gro?
>>
>>
>>    The "insert.gro" file contains the coordinates of one molecule that
>>    you want to insert, i.e. one water molecule.
>>
>>    -Justin
>>
>>           (2) If you haven't re-positioned your system within the box, it
>>           probably doesn't make any sense.  The Gromacs convention is
>>        to place
>>           the corner of the box at the coordinate origin, and
>>        everything else
>>           is relative to that.  Is a 1-nm cubic box large enough to
>>        encompass
>>           your system?  If not, genbox is doing what it's told - filling a
>>           1-nm box near the origin, and leaving everything else out.
>>
>>
>>
>>           -Justin
>>
>>               changing the box size will give a opposite result. Please
>>               advise..Thanks in advance/Jamie
>>
>>
>>
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>>           --    ========================================
>>
>>           Justin A. Lemkul
>>           Ph.D. Candidate
>>           ICTAS Doctoral Scholar
>>           Department of Biochemistry
>>           Virginia Tech
>>           Blacksburg, VA
>>           jalemkul[at]vt.edu <http://vt.edu/> <http://vt.edu/> | (540)
>>        231-9080
>>
>>           http://www.bevanlab.biochem.vt.edu/Pages/Personal/justin
>>
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>>
>>    --    ========================================
>>
>>    Justin A. Lemkul
>>    Ph.D. Candidate
>>    ICTAS Doctoral Scholar
>>    Department of Biochemistry
>>    Virginia Tech
>>    Blacksburg, VA
>>    jalemkul[at]vt.edu <http://vt.edu/> | (540) 231-9080
>>    http://www.bevanlab.biochem.vt.edu/Pages/Personal/justin
>>
>>    ========================================
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>>
>>
> --
> ========================================
>
> Justin A. Lemkul
> Ph.D. Candidate
> ICTAS Doctoral Scholar
> Department of Biochemistry
> Virginia Tech
> Blacksburg, VA
> jalemkul[at]vt.edu | (540) 231-9080
> http://www.bevanlab.biochem.vt.edu/Pages/Personal/justin
>
> ========================================
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