[gmx-users] friction constant for free energy calculation

[minky son]

Dear gmx users,

I was trying to calculate free energy.

I’m confused about setting the appropriate value for friction constant (=
1/tau-t).

In gmx manual, a value of 0.5 ps-1 (tau-t = 2.0 ps) was suggested

but 1.0 ps-1 (tau-t = 1.0 ps) was used in Justin’s tutorial.

How much the results are different by the use of tau-t value 1.0 or 2.0

Thanks in advance.