[gmx-users] bad bond in polymer

Mark Abraham Mark.Abraham at anu.edu.au
Thu Aug 13 06:08:30 CEST 2009


nicegromacs wrote:
> Well, I tried to build a polymer with 3 monomers, DRG DR0 and DR1. In 
> the pdb file They have the same order (DRG DR0 DR1).  But when tried 
> with pdb2gmx then I have the error:
> Fatal error:
> In the .rtp file in residue DR1 at line:
>   CF1   CH3   0   1

There is no such line in the .rtp you provided. GROMACS would normally 
provide more diagnostic information than this. Are you reading it all? 
Are you using the right .rtp files?

> I changed the order of monomers to DR0 DRG DR1 with respect to the 
> ''head'' monomer (DR0), Monomer of in the middle (DRG), and tail monomer 
> (DR1), and the error no change. I have not changed the .hdb file.
> 
> the estructure.ent
> HETATM    1  CAA DRG     1      58.110  44.852  36.809

This first residue listed is named as for your repeating unit. You need 
to make sure the residue naming here matches your connectivity plan.

Mark

> HETATM    2  CAB DRG     1      56.934  44.517  35.875
> HETATM    3  CAC DRG     1      56.190  45.811  35.500
> HETATM    4  CAD DRG     1      55.051  45.476  34.520
> HETATM    5  CAE DRG     1      54.318  46.770  34.118
> HETATM    6  CAF DRG     1      53.310  46.438  33.003
> HETATM    7  CAG DRG     1      52.657  47.686  32.473
> HETATM    8  CAH DRG     1      53.521  48.753  31.851
> HETATM    9  CAI DRG     1      54.199  48.265  30.599
> HETATM   10  CAJ DRG     1      55.615  47.887  30.630
> HETATM   11  OAK DRG     1      56.231  47.370  29.495
> HETATM   12  OAL DRG     1      56.359  48.028  31.798
> HETATM   13  CAM DRG     1      53.423  48.169  29.314
> HETATM   14  CAN DRG     1      52.529  46.963  29.306
> HETATM   15  OAO DRG     1      53.058  45.698  29.542
> HETATM   16  OAP DRG     1      51.206  47.090  28.902
> HETATM   17  CA1 DR0     1      43.743  50.975  25.947
> HETATM   18  CA2 DR0     1      44.674  51.739  26.906
> HETATM   19  CA3 DR0     1      45.313  50.749  27.897
> HETATM   20  CA4 DR0     1      46.248  51.508  28.856
> HETATM   21  CA5 DR0     1      46.862  50.512  29.856
> HETATM   22  CA6 DR0     1      47.789  51.264  30.830
> HETATM   23  CA7 DR0     1      48.356  50.315  31.851
> HETATM   24  CA8 DR0     1      49.361  49.293  31.385
> HETATM   25  CA9 DR0     1      50.545  49.110  32.302
> HETATM   26  C10 DR0     1      51.122  50.259  33.020
> HETATM   27  O12 DR0     1      50.919  51.560  32.571
> HETATM   28  O11 DR0     1      51.877  50.069  34.174
> HETATM   29  C13 DR0     1      51.189  47.782  32.378
> HETATM   30  C14 DR0     1      50.382  46.559  32.210
> HETATM   31  O16 DR0     1      50.972  45.336  31.910
> HETATM   32  O15 DR0     1      48.997  46.595  32.315
> HETATM   33  CF1 DR1     1      55.642  46.172  39.128
> HETATM   34  CF2 DR1     1      54.229  46.780  39.194
> HETATM   35  CF3 DR1     1      53.591  46.765  37.791
> HETATM   36  CF4 DR1     1      52.185  47.384  37.876
> HETATM   37  CF5 DR1     1      51.526  47.395  36.484
> HETATM   38  CF6 DR1     1      50.134  48.044  36.601
> HETATM   39  CF7 DR1     1      49.475  48.098  35.212
> HETATM   40  CF8 DR1     1      48.132  48.846  35.298
> HETATM   41  CF9 DR1     1      47.562  49.035  33.918
> HETATM   42  C1F DR1     1      46.647  48.028  33.366
> HETATM   43  O3F DR1     1      46.397  46.849  34.062
> HETATM   44  O2F DR1     1      45.998  48.241  32.154
> HETATM   45  C4F DR1     1      47.798  50.304  33.215
> HETATM   46  C5F DR1     1      47.426  51.565  33.874
> HETATM   47  O7F DR1     1      47.843  52.791  33.365
> HETATM   48  O6F DR1     1      46.661  51.551  35.036
> CONECT    1    2
> CONECT    2    1    3
> CONECT    3    2    4
> CONECT    4    3    5
> CONECT    5    4    6
> CONECT    6    5    7
> CONECT    7    6    8   29
> CONECT    8    7    9
> CONECT    9    8   10   13
> CONECT   10    9   11   12
> CONECT   11   10
> CONECT   12   10
> CONECT   13    9   14
> CONECT   14   13   15   16
> CONECT   15   14
> CONECT   16   14
> CONECT   17   18
> CONECT   18   17   19
> CONECT   19   18   20
> CONECT   20   19   21
> CONECT   21   20   22
> CONECT   22   21   23
> CONECT   23   22   24   45
> CONECT   24   23   25
> CONECT   25   24   26   29
> CONECT   26   25   27   28
> CONECT   27   26
> CONECT   28   26
> CONECT   29   25   30    7
> CONECT   30   29   31   32
> CONECT   31   30
> CONECT   32   30
> CONECT   33   34
> CONECT   34   33   35
> CONECT   35   34   36
> CONECT   36   35   37
> CONECT   37   36   38
> CONECT   38   37   39
> CONECT   39   38   40
> CONECT   40   39   41
> CONECT   41   40   42   45
> CONECT   42   41   43   44
> CONECT   43   42
> CONECT   44   42
> CONECT   45   41   46   23
> CONECT   46   45   47   48
> CONECT   47   46
> CONECT   48   46
> END
> and the .rtp
> 
> [ DRG ]   ; unidad
> [ atoms ]
>   CAA  CH3    0.00
>   CAB  CH2    0.00
>   CAC  CH2    0.00
>   CAD  CH2    0.00
>   CAE  CH2    0.00
>   CAF  CH2    0.00
>   CAG  CH1    0.00
>   CAH  CH2    0.04
>   CAI  CH1    0.10
>   CAJ    C    0.35
>   OAK   OM   -0.75
>   OAL   OM   -0.75
>   CAM  CH2    0.04
>   CAN    C    0.37
>   OAO   OM   -0.70
>   OAP   OM   -0.70
> [ bonds ]
>   CAM -CAG
>   CAA  CAB
>   CAB  CAC
>   CAC  CAD
>   CAD  CAE
>   CAE  CAF
>   CAF  CAG
>   CAG  CAH
>   CAH  CAI
>   CAI  CAJ
>   CAI  CAM
>   CAJ  OAK
>   CAJ  OAL
>   CAM  CAN
>   CAN  OAO
>   CAN  OAP
>   CAG +CAM
> [ impropers ]
>   CAG  CAF -CAM  C
>  -CAM -CAN -CAI  C
>   CAJ  CAI  OAL  O
>   CAN  CAM  OAP  O
>   CAI  CAH  CAJ  C
> 
> [ DR0 ]   ;head of
> [ atoms ]
>   CA1  CH3    0.00
>   CA2  CH2    0.00
>   CA3  CH2    0.00
>   CA4  CH2    0.00
>   CA5  CH2    0.00
>   CA6  CH2    0.00
>   CA7  CH2    0.00
>   CA8  CH2    0.04
>   CA9  CH1    0.10
>   C10    C    0.35
>   O12   OM   -0.75
>   O11   OM   -0.75
>   C13  CH2    0.04
>   C14    C    0.37
>   O16   OM   -0.70
>   O15   OM   -0.70
> [ bonds ]
>   CA1  CA2
>   CA2  CA3
>   CA3  CA4
>   CA4  CA5
>   CA5  CA6
>   CA6  CA7
>   CA7  CA8
>   CA8  CA9
>   CA9  C10
>   CA9  C13
>   C10  O12
>   C10  O11
>   C13  C14
>   C14  O16
>   C14  O15
>   CA7 +CAM
> [ impropers ]
> CA7  CA6 +CAM  CA8
> +CAM +CAI +CAN  CA7
> C10  CA9  O11  O12
> C14  C13  O15  O16
> CA9  CA8  C10  C13
> 
> [ DR1 ] ; tail of t
>   CF1  CH3    0.00
>   CF2  CH2    0.00
>   CF3  CH2    0.00
>   CF4  CH2    0.00
>   CF5  CH2    0.00
>   CF6  CH2    0.00
>   CF7  CH2    0.00
>   CF8  CH2    0.04
>   CF9  CH1    0.10
>   C1F    C    0.35
>   O3F   OM   -0.75
>   O2F   OM   -0.75
>   C4F  CH2    0.04
>   C5F    C    0.37
>   O7F   OM   -0.70
>   O6F   OM   -0.70
> [ bonds ]
>   C4F -CAG
>   CF1  CF2
>   CF2  CF3
>   CF3  CF4
>   CF4  CF5
>   CF5  CF6
>   CF6  CF7
>   CF7  CF8
>   CF8  CF9
>   CF9  C1F
>   CF9  C4F
>   C1F  O3F
>   C1F  O2F
>   C4F  C5F
>   C5F  O7F
>   C5F  O6F
> [ impropers ]
> C4F  C5F  CF9 -CAG
> -CAG -CAF -CAH  C4F
> C1F  CF9  O2F  O3F
> C5F  C4F  O6F  O7F
> CF9  CF8  C1F  C4F
> 
> 
> --------------------------------------------------
> From: "Justin A. Lemkul" <jalemkul at vt.edu>
> Sent: Wednesday, August 12, 2009 9:50 PM
> To: "Gromacs Users' List" <gmx-users at gromacs.org>
> Subject: Re: [gmx-users] bad bond in polymer
> 
>>
>>
>> nicegromacs wrote:
>>
>>>   CAG -CAM
>>
>> Defining a bond to a previous residue will certainly fail for at least 
>> one terminus of your polymer chain.  You may find this post useful:
>>
>> http://oldwww.gromacs.org/pipermail/gmx-users/2009-March/040125.html
>>
>> If things still aren't working, please post the structure file, as 
>> well, and identify the bond that is being formed that shouldn't.
>>
>> -Justin
>>
>> -- 
>> ========================================
>>
>> Justin A. Lemkul
>> Ph.D. Candidate
>> ICTAS Doctoral Scholar
>> Department of Biochemistry
>> Virginia Tech
>> Blacksburg, VA
>> jalemkul[at]vt.edu | (540) 231-9080
>> http://www.bevanlab.biochem.vt.edu/Pages/Personal/justin
>>
>> ========================================
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