[gmx-users] .top file from .gro file

Justin A. Lemkul jalemkul at vt.edu
Thu Aug 20 00:09:53 CEST 2009



sunny mishra wrote:
> Hi,
> 
> I checked both the files they match exactly but still I get the same 
> error message that .gro file and .top file dnt match. I dnt know how to 
> proceed now.
> 

Well, something has to be wrong, or else grompp wouldn't complain.  You say 
you've checked the .top, but have you also checked the contents of any relevant 
.itp files that are #included within it?

-Justin

> Sunny
> 
> On Tue, Aug 18, 2009 at 8:18 PM, sunny mishra <mishra.sunny at gmail.com 
> <mailto:mishra.sunny at gmail.com>> wrote:
> 
>     Ok..I will see that and let you know. Thanks for the help though.
> 
>     Sunny
> 
> 
>     On Tue, Aug 18, 2009 at 8:12 PM, Mark Abraham
>     <Mark.Abraham at anu.edu.au <mailto:Mark.Abraham at anu.edu.au>> wrote:
> 
>         sunny mishra wrote:
> 
>             I did the same but again i get the same error..something
>             like this
> 
>             awk -f atom2cg_v2.1tryout.awk 1K4C.pdb > 1K4C_cg.pdb
> 
>             (This generated 1K4C_cg.pdb file)
> 
>             genbox -cp 1K4C_cg.pdb -box 10 10 10 -o 1K4C_cg.gro
> 
>             (produced 1K4C_cg.gro)
> 
>             GROningen MAchine for Chemical Simulation
> 
>                                        :-)  VERSION 4.0.5  (-:
> 
> 
>                  Written by David van der Spoel, Erik Lindahl, Berk
>             Hess, and others.
>                   Copyright (c) 1991-2000, University of Groningen, The
>             Netherlands.
>                         Copyright (c) 2001-2008, The GROMACS development
>             team,
>                        check out http://www.gromacs.org for more
>             information.
> 
>                     This program is free software; you can redistribute
>             it and/or
>                      modify it under the terms of the GNU General Public
>             License
>                     as published by the Free Software Foundation; either
>             version 2
>                         of the License, or (at your option) any later
>             version.
> 
>                                            :-)  genbox  (-:
> 
>             Option     Filename  Type         Description
>             ------------------------------------------------------------
>              -cp    1K4C_cg.pdb  Input, Opt!  Structure file: gro g96
>             pdb tpr tpb tpa
>              -cs     spc216.gro  Input, Opt., Lib. Structure file: gro
>             g96 pdb tpr tpb
>             tpa
>              -ci     insert.gro  Input, Opt.  Structure file: gro g96
>             pdb tpr tpb
>             tpa
>              -o    1K4C_cg.gro  Output       Structure file: gro g96
>             pdb
>              -p      topol.top  In/Out, Opt. Topology
>             file
> 
>             Option       Type   Value   Description
>             ------------------------------------------------------
>             -[no]h       bool   no      Print help info and quit
>             -nice        int    19      Set the nicelevel
>             -box         vector 10 10 10  box size
>             -nmol        int    0       no of extra molecules to insert
>             -try         int    10      try inserting -nmol*-try times
>             -seed        int    1997    random generator seed
>             -vdwd        real   0.105   default vdwaals distance
>             -shell       real   0       thickness of optional water
>             layer around solute
>             -maxsol      int    0       maximum number of solvent
>             molecules to add if
>                                        they fit in the box. If zero
>             (default) this is
>                                        ignored
>             -[no]vel     bool   no      keep velocities from input
>             solute and solvent
> 
>             Opening library file
>             /usr/local/gromacs/share/gromacs/top/aminoacids.dat
>             WARNING: masses will be determined based on residue and atom
>             names,
>                     this can deviate from the real mass of the atom type
>             Opening library file
>             /usr/local/gromacs/share/gromacs/top/atommass.dat
>             Entries in atommass.dat: 178
>             WARNING: vdwradii will be determined based on residue and
>             atom names,
>                     this can deviate from the real mass of the atom type
>             Opening library file
>             /usr/local/gromacs/share/gromacs/top/vdwradii.dat
>             Entries in vdwradii.dat: 28
>             Opening library file
>             /usr/local/gromacs/share/gromacs/top/dgsolv.dat
>             Entries in dgsolv.dat: 7
>             Opening library file
>             /usr/local/gromacs/share/gromacs/top/electroneg.dat
>             Entries in electroneg.dat: 71
>             Opening library file
>             /usr/local/gromacs/share/gromacs/top/elements.dat
>             Entries in elements.dat: 218
>             Reading solute configuration
>             MEMBRANE PROTEIN
>             Containing 1127 atoms in 534 residues
>             Initialising van der waals distances...
>             Writing generated configuration to 1K4C_cg.gro
>             MEMBRANE PROTEIN
> 
>             Output configuration contains 1127 atoms in 534 residues
>             Volume                 :        1000 (nm^3)
>             Density                :     53.8545 (g/l)
>             Number of SOL molecules:      0
> 
> 
>             gcq#69: "I Want to Know Right Now" (Meatloaf)
> 
> 
>             After that ;;;;;;;;;;;;;;;;;;;;;;;
> 
>             grompp -f em.mdp -c 1K4C_cg.gro -p 1K4C.top -maxwarn 10
> 
>                                     :-)  G  R  O  M  A  C  S
>             (-:
> 
>                         Gallium Rubidium Oxygen Manganese Argon Carbon
>             Silicon
> 
>                                        :-)  VERSION 4.0.5  (-:
> 
> 
>                  Written by David van der Spoel, Erik Lindahl, Berk
>             Hess, and others.
>                   Copyright (c) 1991-2000, University of Groningen, The
>             Netherlands.
>                         Copyright (c) 2001-2008, The GROMACS development
>             team,
>                        check out http://www.gromacs.org for more
>             information.
> 
>                     This program is free software; you can redistribute
>             it and/or
>                      modify it under the terms of the GNU General Public
>             License
>                     as published by the Free Software Foundation; either
>             version 2
>                         of the License, or (at your option) any later
>             version.
> 
>                                            :-)  grompp  (-:
> 
>             Option     Filename  Type         Description
>             ------------------------------------------------------------
>              -f         em.mdp  Input, Opt!  grompp input file with MD
>             parameters
>              -po      mdout.mdp  Output       grompp input file with MD
>             parameters
>              -c    1K4C_cg.gro  Input        Structure file: gro g96 pdb
>             tpr tpb tpa
>              -r       conf.gro  Input, Opt.  Structure file: gro g96 pdb
>             tpr tpb tpa
>              -rb       conf.gro  Input, Opt.  Structure file: gro g96
>             pdb tpr tpb tpa
>              -n      index.ndx  Input, Opt.  Index file
>              -p       1K4C.top  Input        Topology file
>              -pp  processed.top  Output, Opt. Topology file
>              -o      topol.tpr  Output       Run input file: tpr tpb tpa
>              -t       traj.trr  Input, Opt.  Full precision trajectory:
>             trr trj cpt
>              -e       ener.edr  Input, Opt.  Energy file: edr ene
> 
>             Option       Type   Value   Description
>             ------------------------------------------------------
>             -[no]h       bool   no      Print help info and quit
>             -nice        int    0       Set the nicelevel
>             -[no]v       bool   yes     Be loud and noisy
>             -time        real   -1      Take frame at or first after
>             this time.
>             -[no]rmvsbds bool   yes     Remove constant bonded
>             interactions with virtual
>                                        sites
>             -maxwarn     int    10      Number of allowed warnings
>             during input
>             processing
>             -[no]zero    bool   no      Set parameters for bonded
>             interactions
>             without
>                                        defaults to zero instead of
>             generating an
>             error
>             -[no]renum   bool   yes     Renumber atomtypes and minimize
>             number
>             of
> 
>             atomtypes
> 
>             Ignoring obsolete mdp entry 'title'
>             Ignoring obsolete mdp entry 'cpp'
>             Replacing old mdp entry 'unconstrained_start' by 'continuation'
> 
>             Back Off! I just backed up mdout.mdp to ./#mdout.mdp.9#
>             checking input for internal consistency...
> 
>             NOTE 1 [file em.mdp, line unknown]:
>              For energy conservation with switch/shift potentials, rlist
>             should be 0.1
>              to 0.3 nm larger than rcoulomb.
> 
> 
>             NOTE 2 [file em.mdp, line unknown]:
>              For energy conservation with switch/shift potentials, rlist
>             should be 0.1
>              to 0.3 nm larger than rvdw.
> 
>             processing topology...
>             Generated 0 of the 465 non-bonded parameter combinations
>             Excluding 1 bonded neighbours molecule type 'Protein'
> 
>             NOTE 3 [file 1K4C.top, line 15]:
>              System has non-zero total charge: 4.000000e+00
> 
> 
> 
>             processing coordinates...
> 
>             -------------------------------------------------------
>             Program grompp, VERSION 4.0.5
>             Source code file: grompp.c, line: 362
> 
>             Fatal error:
>             number of coordinates in coordinate file (1K4C_cg.gro, 1127)
>                         does not match topology (1K4C.top, 1166)
>             -------------------------------------------------------
> 
> 
>         That's a pretty explicit error message. Go and look at the
>         molecule and atom ordering in the two files and see where they
>         don't match.
> 
>         Mark
> 
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> 
> 
> 
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> 
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-- 
========================================

Justin A. Lemkul
Ph.D. Candidate
ICTAS Doctoral Scholar
Department of Biochemistry
Virginia Tech
Blacksburg, VA
jalemkul[at]vt.edu | (540) 231-9080
http://www.bevanlab.biochem.vt.edu/Pages/Personal/justin

========================================



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