[gmx-users] MDRUN crash

Luca Banetta luca.banetta at gmail.com
Fri Jun 17 13:52:07 CEST 2016


thank you for your great useful help justin! I have just written two
directives in which I declare polarization and exlusions as you wrote
me on the previous e-mail

[ polarization ]
;   Vsite      shell   functiontype  alpha nm^3
      11         12        1            0.001
[ exclusions ]
;
4 1 2 3 5 6 7 8 9 10 11 12
11 1 2 3 4 5 6 7 8 9 10 12

The mdp file is the following one

;
;    File 'mdout.mdp' was generated
;    By user: onbekend (0)
;    On host: onbekend
;    At date: Fri Jun 17 13:45:51 2016
;

; VARIOUS PREPROCESSING OPTIONS
; Preprocessor information: use cpp syntax.
; e.g.: -I/home/joe/doe -I/home/mary/roe
include                  =
; e.g.: -DPOSRES -DFLEXIBLE (note these variable names are case sensitive)
define                   =

; RUN CONTROL PARAMETERS
integrator               = md
; Start time and timestep in ps
tinit                    = 0
dt                       = 0.0001
nsteps                   = 1000000
; For exact run continuation or redoing part of a run
init_step                = 0
; Part index is updated automatically on checkpointing (keeps files separate)
simulation_part          = 1
; mode for center of mass motion removal
comm-mode                = Linear
; number of steps for center of mass motion removal
nstcomm                  = 1
; group(s) for center of mass motion removal
comm-grps                =

; LANGEVIN DYNAMICS OPTIONS
; Friction coefficient (amu/ps) and random seed
bd-fric                  = 0
ld-seed                  = 1993

; ENERGY MINIMIZATION OPTIONS
; Force tolerance and initial step-size
emtol                    = 100
emstep                   = 0.01
; Max number of iterations in relax_shells
niter                    = 20
; Step size (ps^2) for minimization of flexible constraints
fcstep                   = 0
; Frequency of steepest descents steps when doing CG
nstcgsteep               = 1000
nbfgscorr                = 10

; TEST PARTICLE INSERTION OPTIONS
rtpi                     = 0.05

; OUTPUT CONTROL OPTIONS
; Output frequency for coords (x), velocities (v) and forces (f)
nstxout                  = 100
nstvout                  = 100
nstfout                  = 0
; Output frequency for energies to log file and energy file
nstlog                   = 50
nstcalcenergy            = -1
nstenergy                = 50
; Output frequency and precision for .xtc file
nstxtcout                = 50
xtc-precision            = 1000
; This selects the subset of atoms for the .xtc file. You can
; select multiple groups. By default all atoms will be written.
xtc-grps                 =
; Selection of energy groups
energygrps               =

; NEIGHBORSEARCHING PARAMETERS
; nblist update frequency
nstlist                  = 5
; ns algorithm (simple or grid)
ns_type                  = grid
; Periodic boundary conditions: xyz, no, xy
pbc                      = xyz
periodic_molecules       = no
; nblist cut-off
rlist                    = 0.9
; long-range cut-off for switched potentials
rlistlong                = -1

; OPTIONS FOR ELECTROSTATICS AND VDW
; Method for doing electrostatics
coulombtype              = PME
rcoulomb-switch          = 0
rcoulomb                 = 0.9
; Relative dielectric constant for the medium and the reaction field
epsilon-r                = 1
epsilon_rf               = 1
; Method for doing Van der Waals
vdw-type                 = Cut-off
; cut-off lengths
rvdw-switch              = 0
rvdw                     = 0.9
; Apply long range dispersion corrections for Energy and Pressure
DispCorr                 = EnerPres
; Extension of the potential lookup tables beyond the cut-off
table-extension          = 1
; Seperate tables between energy group pairs
energygrp_table          =
; Spacing for the PME/PPPM FFT grid
fourierspacing           = 0.12
; FFT grid size, when a value is 0 fourierspacing will be used
fourier_nx               = 0
fourier_ny               = 0
fourier_nz               = 0
; EWALD/PME/PPPM parameters
pme_order                = 4
ewald_rtol               = 1e-05
ewald_geometry           = 3d
epsilon_surface          = 0
optimize_fft             = no

; IMPLICIT SOLVENT ALGORITHM
implicit_solvent         = No

; GENERALIZED BORN ELECTROSTATICS
; Algorithm for calculating Born radii
gb_algorithm             = Still
; Frequency of calculating the Born radii inside rlist
nstgbradii               = 1
; Cutoff for Born radii calculation; the contribution from atoms
; between rlist and rgbradii is updated every nstlist steps
rgbradii                 = 2
; Dielectric coefficient of the implicit solvent
gb_epsilon_solvent       = 80
; Salt concentration in M for Generalized Born models
gb_saltconc              = 0
; Scaling factors used in the OBC GB model. Default values are OBC(II)
gb_obc_alpha             = 1
gb_obc_beta              = 0.8
gb_obc_gamma             = 4.85
gb_dielectric_offset     = 0.009
sa_algorithm             = Ace-approximation
; Surface tension (kJ/mol/nm^2) for the SA (nonpolar surface) part of GBSA
; The value -1 will set default value for Still/HCT/OBC GB-models.
sa_surface_tension       = -1

; OPTIONS FOR WEAK COUPLING ALGORITHMS
; Temperature coupling
Tcoupl                   = v-rescale
nsttcouple               = -1
nh-chain-length          = 10
; Groups to couple separately
tc-grps                  = System
; Time constant (ps) and reference temperature (K)
tau_t                    = 0.1
ref_t                    = 300
; Pressure coupling
Pcoupl                   = berendsen
Pcoupltype               = isotropic
nstpcouple               = -1
; Time constant (ps), compressibility (1/bar) and reference P (bar)
tau_p                    = 1.0
compressibility          = 4.5e-5
ref_p                    = 1.0
; Scaling of reference coordinates, No, All or COM
refcoord_scaling         = No
; Random seed for Andersen thermostat
andersen_seed            = 815131

; OPTIONS FOR QMMM calculations
QMMM                     = no
; Groups treated Quantum Mechanically
QMMM-grps                =
; QM method
QMmethod                 =
; QMMM scheme
QMMMscheme               = normal
; QM basisset
QMbasis                  =
; QM charge
QMcharge                 =
; QM multiplicity
QMmult                   =
; Surface Hopping
SH                       =
; CAS space options
CASorbitals              =
CASelectrons             =
SAon                     =
SAoff                    =
SAsteps                  =
; Scale factor for MM charges
MMChargeScaleFactor      = 1
; Optimization of QM subsystem
bOPT                     =
bTS                      =

; SIMULATED ANNEALING
; Type of annealing for each temperature group (no/single/periodic)
annealing                = no
; Number of time points to use for specifying annealing in each group
annealing_npoints        =
; List of times at the annealing points for each group
annealing_time           =
; Temp. at each annealing point, for each group.
annealing_temp           =

; GENERATE VELOCITIES FOR STARTUP RUN
gen_vel                  = yes
gen_temp                 = 300
gen_seed                 = 1993

; OPTIONS FOR BONDS
constraints              = all-bonds
; Type of constraint algorithm
constraint-algorithm     = Lincs
; Do not constrain the start configuration
continuation             = no
; Use successive overrelaxation to reduce the number of shake iterations
Shake-SOR                = no
; Relative tolerance of shake
shake-tol                = 1e-04
; Highest order in the expansion of the constraint coupling matrix
lincs-order              = 4
; Number of iterations in the final step of LINCS. 1 is fine for
; normal simulations, but use 2 to conserve energy in NVE runs.
; For energy minimization with constraints it should be 4 to 8.
lincs-iter               = 1
; Lincs will write a warning to the stderr if in one step a bond
; rotates over more degrees than
lincs-warnangle          = 30
; Convert harmonic bonds to morse potentials
morse                    = no

; ENERGY GROUP EXCLUSIONS
; Pairs of energy groups for which all non-bonded interactions are excluded
energygrp_excl           =

; WALLS
; Number of walls, type, atom types, densities and box-z scale factor for Ewald
nwall                    = 0
wall_type                = 9-3
wall_r_linpot            = -1
wall_atomtype            =
wall_density             =
wall_ewald_zfac          = 3

; COM PULLING
; Pull type: no, umbrella, constraint or constant_force
pull                     = no

; NMR refinement stuff
; Distance restraints type: No, Simple or Ensemble
disre                    = No
; Force weighting of pairs in one distance restraint: Conservative or Equal
disre-weighting          = Conservative
; Use sqrt of the time averaged times the instantaneous violation
disre-mixed              = no
disre-fc                 = 1000
disre-tau                = 0
; Output frequency for pair distances to energy file
nstdisreout              = 100
; Orientation restraints: No or Yes
orire                    = no
; Orientation restraints force constant and tau for time averaging
orire-fc                 = 0
orire-tau                = 0
orire-fitgrp             =
; Output frequency for trace(SD) and S to energy file
nstorireout              = 100
; Dihedral angle restraints: No or Yes
dihre                    = No
dihre-fc                 = 1000

; Free energy control stuff
free-energy              = no
init-lambda              = 0
delta-lambda             = 0
foreign_lambda           =
sc-alpha                 = 0
sc-power                 = 0
sc-sigma                 = 0.3
nstdhdl                  = 10
separate-dhdl-file       = yes
dhdl-derivatives         = yes
dh_hist_size             = 0
dh_hist_spacing          = 0.1
couple-moltype           =
couple-lambda0           = vdw-q
couple-lambda1           = vdw-q
couple-intramol          = no

; Non-equilibrium MD stuff
acc-grps                 =
accelerate               =
freezegrps               =
freezedim                =
cos-acceleration         = 0
deform                   =

; Electric fields
; Format is number of terms (int) and for all terms an amplitude (real)
; and a phase angle (real)
E-x                      =
E-xt                     =
E-y                      =
E-yt                     =
E-z                      =
E-zt                     =

; User defined thingies
user1-grps               =
user2-grps               =
userint1                 = 0
userint2                 = 0
userint3                 = 0
userint4                 = 0
userreal1                = 0
userreal2                = 0
userreal3                = 0
userreal4                = 0


But unfortunately immediately after I launch the mdrun this fatal error appears:

Fatal error:
1629 particles communicated to PME node 4 are more than 2/3 times the
cut-off out of the domain decomposition cell of their charge group in
dimension x.
This usually means that your system is not well equilibrated.

What can i do in order to fix it?

2016-06-17 12:03 GMT+02:00 Justin Lemkul <jalemkul at vt.edu>:
>
>
> On 6/17/16 3:56 AM, Luca Banetta wrote:
>>
>> Thank you for your support mark! I run an equilibration with a simple
>> acetone molecule and it works with the mdp file i wrote in the first
>> e-mail. I try to take a look at the shell to see if i made mistakes in its
>> definition.
>
>
> Yes, the topology is wrong if you're trying to use a polarizable model.  You
> have a virtual particle (11) with a negative charge and (presumably) a shell
> particle with an equivalent charge, defined as being bonded to the virtual
> particle.  But it's not actually a polarizable system (you need to define a
> [polarization] directive with the attributes of the shell, e.g. atomic
> polarizability) and you need to exclude the virtual site from the shell and
> the other atoms that the O atom is excluded from.  Without doing this,
> you're just generating huge forces on everything due to electrostatic
> repulsion.
>
> -Justin
>
>
>> Il 17/Giu/2016 08:47, "Mark Abraham" <mark.j.abraham at gmail.com> ha
>> scritto:
>>
>>> Hi,
>>>
>>> Please don't start new work with old out-of-maintenance software, or at
>>> least use the most recent bug fix from that release branch. You should
>>> also
>>> do an equilibration with a normal acetone first, so that you know whether
>>> it's your equilibration or your shell model that is the problem.
>>>
>>> Mark
>>>
>>> On Fri, Jun 17, 2016 at 8:44 AM Luca Banetta <luca.banetta at gmail.com>
>>> wrote:
>>>
>>>> thank you for the advice justin! i have made some research and i use PME
>>>> for electrostatics that i noticed it's pretty common. Unfortunately the
>>>> mdrun this fatal error appeared:
>>>> Program mdrun, VERSION 4.5.4
>>>> Source code file: pme.c, line: 538
>>>>
>>>> Fatal error:
>>>> 1629 particles communicated to PME node 4 are more than 2/3 times the
>>>> cut-off out of the domain decomposition cell of their charge group in
>>>> dimension x.
>>>> This usually means that your system is not well equilibrated.
>>>>
>>>>
>>>> For out simulation we created a topology for the acetone molecule using
>>>> opls-AA force field introudicing a shell particle inside the topology.
>>>> At the moment the simulation is based on a single acetone molecule
>>>
>>> inside a
>>>>
>>>> "sea" of water.
>>>> [ moleculetype ]
>>>> ; Name            nrexcl
>>>> acetone               3
>>>>
>>>> [ atoms ]
>>>> ;   nr       type          resnr   residue      atom      cgnr   charge
>>>> mass  typeB    chargeB    massB
>>>>          1  opls_280         1       LIG         C         1      0.47
>>>> 12.011
>>>>          2  opls_135         1       LIG         C         2     -0.18
>>>> 12.011
>>>>          3  opls_135         1       LIG         C         3     -0.18
>>>> 12.011
>>>>          4  opls_281         1       LIG         O         4      0.47
>>>> 15.5994
>>>>          5  opls_282         1       LIG         H         5      0.06
>>>> 1.008
>>>>          6  opls_282         1       LIG         H         6      0.06
>>>> 1.008
>>>>          7  opls_282         1       LIG         H         7      0.06
>>>> 1.008
>>>>          8  opls_282         1       LIG         H         8      0.06
>>>> 1.008
>>>>          9  opls_282         1       LIG         H         9      0.06
>>>> 1.008
>>>>         10  opls_282        1       LIG         H        10      0.06
>>>> 1.008
>>>>         11     VS              1       LIG         VS       11
>>>> -0.47     0.000
>>>>         12     SP              1       LIG         SP       12
>>>> -0.47     0.000
>>>>
>>>> [ bonds ]
>>>> ;  ai    aj funct            c0            c1            c2
>>>> c3
>>>>     1     2     1
>>>>     1     3     1
>>>>     1     4     1
>>>>     4     11    6
>>>>     11    12    6
>>>>     2     5     1
>>>>     2     6     1
>>>>     2     7     1
>>>>     3     8     1
>>>>     3     9     1
>>>>     3    10     1
>>>>
>>>> [ pairs ]
>>>> ;  ai    aj funct            c0            c1            c2
>>>> c3
>>>>     2     8     1
>>>>     2     9     1
>>>>     2    10     1
>>>>     3     5     1
>>>>     3     6     1
>>>>     3     7     1
>>>>     4     5     1
>>>>     4     6     1
>>>>     4     7     1
>>>>     4     8     1
>>>>     4     9     1
>>>>     4    10     1
>>>>
>>>> [ angles ]
>>>> ;  ai    aj    ak funct            c0            c1
>>>> c2            c3
>>>>     2     1     3     1
>>>>     2     1     4     1
>>>>     3     1     4     1
>>>>     1     2     5     1
>>>>     1     2     6     1
>>>>     1     2     7     1
>>>>     5     2     6     1
>>>>     5     2     7     1
>>>>     6     2     7     1
>>>>     1     3     8     1
>>>>     1     3     9     1
>>>>     1     3    10     1
>>>>     8     3     9     1
>>>>     8     3    10     1
>>>>     9     3    10     1
>>>>
>>>> [ dihedrals ]
>>>> ;  ai    aj    ak    al funct            c0            c1
>>>> c2            c3            c4            c5
>>>>     3     1     2     5     3
>>>>     3     1     2     6     3
>>>>     3     1     2     7     3
>>>>     4     1     2     5     3
>>>>     4     1     2     6     3
>>>>     4     1     2     7     3
>>>>     2     1     3     8     3
>>>>     2     1     3     9     3
>>>>     2     1     3    10     3
>>>>     4     1     3     8     3
>>>>     4     1     3     9     3
>>>>     4     1     3    10     3
>>>>
>>>> [ virtual_sites2 ]
>>>> ; site  ai  aj  funct   a
>>>>     11   1   4    1     1.05
>>>>
>>>> VS and SP have been introduced in the "ffnonbonded" and "ffbonded"
>>>
>>> sections
>>>>
>>>> in the library oplsaa.ff
>>>>
>>>> 2016-06-16 15:05 GMT+02:00 Justin Lemkul <jalemkul at vt.edu>:
>>>>
>>>>>
>>>>>
>>>>> On 6/16/16 6:10 AM, Luca Banetta wrote:
>>>>>
>>>>>> Dear gmx users,
>>>>>> I am meeting a lot of problems launching a simulation with shell
>>>>>> particles.
>>>>>> The mdp file is
>>>>>> ; VARIOUS PREPROCESSING OPTIONS
>>>>>> title                    = Yo
>>>>>> cpp                      = /usr/bin/cpp
>>>>>> include                  =
>>>>>> define                   =
>>>>>>
>>>>>> ; RUN CONTROL PARAMETERS
>>>>>> integrator               = md
>>>>>> ; Start time and timestep in ps
>>>>>> tinit                    = 0
>>>>>> dt                       = 0.001
>>>>>> nsteps                   = 1000000
>>>>>> ; For exact run continuation or redoing part of a run
>>>>>> init_step                = 0
>>>>>> ; mode for center of mass motion removal
>>>>>> comm-mode                = Linear
>>>>>> ; number of steps for center of mass motion removal
>>>>>> nstcomm                  = 1
>>>>>> ; group(s) for center of mass motion removal
>>>>>> comm-grps                =
>>>>>>
>>>>>> ; LANGEVIN DYNAMICS OPTIONS
>>>>>> ; Temperature, friction coefficient (amu/ps) and random seed
>>>>>> bd-temp                  = 300
>>>>>> bd-fric                  = 0
>>>>>> ld-seed                  = 1993
>>>>>>
>>>>>> ; ENERGY MINIMIZATION OPTIONS
>>>>>> ; Force tolerance and initial step-size
>>>>>> emtol                    = 100
>>>>>> emstep                   = 0.01
>>>>>> ; Max number of iterations in relax_shells
>>>>>> niter                    = 20
>>>>>> ; Step size (1/ps^2) for minimization of flexible constraints
>>>>>> fcstep                   = 0
>>>>>> ; Frequency of steepest descents steps when doing CG
>>>>>> nstcgsteep               = 1000
>>>>>> nbfgscorr                = 10
>>>>>>
>>>>>> ; OUTPUT CONTROL OPTIONS
>>>>>> ; Output frequency for coords (x), velocities (v) and forces (f)
>>>>>> nstxout                  =
>>>>>> nstvout                  =
>>>>>> nstfout                  =
>>>>>> ; Checkpointing helps you continue after crashes
>>>>>> nstcheckpoint            = 1000
>>>>>> ; Output frequency for energies to log file and energy file
>>>>>> nstlog                   = 50
>>>>>> nstenergy                = 50
>>>>>> ; Output frequency and precision for xtc file
>>>>>> nstxtcout                = 50
>>>>>> xtc-precision            = 1000
>>>>>> ; This selects the subset of atoms for the xtc file. You can
>>>>>> ; select multiple groups. By default all atoms will be written.
>>>>>> xtc-grps                 =
>>>>>> ; Selection of energy groups
>>>>>> energygrps               =
>>>>>>
>>>>>> ; NEIGHBORSEARCHING PARAMETERS
>>>>>> ; nblist update frequency
>>>>>> nstlist                  = 5
>>>>>> ; ns algorithm (simple or grid)
>>>>>> ns_type                  = grid
>>>>>> ; Periodic boundary conditions: xyz (default), no (vacuum)
>>>>>> ; or full (infinite systems only)
>>>>>> pbc                      = xyz
>>>>>> ; nblist cut-off
>>>>>> rlist                    = 0.9
>>>>>> domain-decomposition     = no
>>>>>>
>>>>>> ; OPTIONS FOR ELECTROSTATICS AND VDW
>>>>>> ; Method for doing electrostatics
>>>>>> coulombtype              = Cut-off
>>>>>> rcoulomb-switch          = 0
>>>>>> rcoulomb                 = 0.9
>>>>>> ; Dielectric constant (DC) for cut-off or DC of reaction field
>>>>>> epsilon-r                = 1
>>>>>> ; Method for doing Van der Waals
>>>>>> vdw-type                 = Cut-off
>>>>>> ; cut-off lengths
>>>>>> rvdw-switch              = 0
>>>>>> rvdw                     = 0.9
>>>>>> ; Apply long range dispersion corrections for Energy and Pressure
>>>>>> DispCorr                 = EnerPres
>>>>>> ; Extension of the potential lookup tables beyond the cut-off
>>>>>> table-extension          = 1
>>>>>> ; Spacing for the PME/PPPM FFT grid
>>>>>> fourierspacing           = 0.12
>>>>>> ; FFT grid size, when a value is 0 fourierspacing will be used
>>>>>> fourier_nx               = 0
>>>>>> fourier_ny               = 0
>>>>>> fourier_nz               = 0
>>>>>> ; EWALD/PME/PPPM parameters
>>>>>> pme_order                = 4
>>>>>> ewald_rtol               = 1e-05
>>>>>> ewald_geometry           = 3d
>>>>>> epsilon_surface          = 0
>>>>>> optimize_fft             = no
>>>>>>
>>>>>> ; GENERALIZED BORN ELECTROSTATICS
>>>>>> ; Algorithm for calculating Born radii
>>>>>> gb_algorithm             = Still
>>>>>> ; Frequency of calculating the Born radii inside rlist
>>>>>> nstgbradii               = 1
>>>>>> ; Cutoff for Born radii calculation; the contribution from atoms
>>>>>> ; between rlist and rgbradii is updated every nstlist steps
>>>>>> rgbradii                 = 2
>>>>>> ; Salt concentration in M for Generalized Born models
>>>>>> gb_saltconc              = 0
>>>>>>
>>>>>> ; IMPLICIT SOLVENT (for use with Generalized Born electrostatics)
>>>>>> implicit_solvent         = No
>>>>>>
>>>>>> ; OPTIONS FOR WEAK COUPLING ALGORITHMS
>>>>>> ; Temperature coupling
>>>>>> Tcoupl                   = berendsen
>>>>>> ; Groups to couple separately
>>>>>> tc-grps                  = System
>>>>>> ; Time constant (ps) and reference temperature (K)
>>>>>> tau_t                    = 0.1
>>>>>> ref_t                    = 300
>>>>>> ; Pressure coupling
>>>>>> Pcoupl                   = berendsen
>>>>>> Pcoupltype               = isotropic
>>>>>> ; Time constant (ps), compressibility (1/bar) and reference P (bar)
>>>>>> tau_p                    = 1.0
>>>>>> compressibility          = 4.5e-5
>>>>>> ref_p                    = 1.0
>>>>>> ; Random seed for Andersen thermostat
>>>>>> andersen_seed            = 815131
>>>>>>
>>>>>> ; SIMULATED ANNEALING
>>>>>> ; Type of annealing for each temperature group (no/single/periodic)
>>>>>> annealing                = no
>>>>>> ; Number of time points to use for specifying annealing in each group
>>>>>> annealing_npoints        =
>>>>>> ; List of times at the annealing points for each group
>>>>>> annealing_time           =
>>>>>> ; Temp. at each annealing point, for each group.
>>>>>> annealing_temp           =
>>>>>>
>>>>>> ; GENERATE VELOCITIES FOR STARTUP RUN
>>>>>> gen_vel                  = yes
>>>>>> gen_temp                 = 300
>>>>>> gen_seed                 = 1993
>>>>>>
>>>>>> ; OPTIONS FOR BONDS
>>>>>> constraints              = all-bonds
>>>>>> ; Type of constraint algorithm
>>>>>> constraint-algorithm     = Lincs
>>>>>> ; Do not constrain the start configuration
>>>>>> unconstrained-start      = no
>>>>>> ; Use successive overrelaxation to reduce the number of shake
>>>
>>> iterations
>>>>>>
>>>>>> Shake-SOR                = no
>>>>>> ; Relative tolerance of shake
>>>>>> shake-tol                = 1e-04
>>>>>> ; Highest order in the expansion of the constraint coupling matrix
>>>>>> lincs-order              = 4
>>>>>> ; Number of iterations in the final step of LINCS. 1 is fine for
>>>>>> ; normal simulations, but use 2 to conserve energy in NVE runs.
>>>>>> ; For energy minimization with constraints it should be 4 to 8.
>>>>>> lincs-iter               = 1
>>>>>> ; Lincs will write a warning to the stderr if in one step a bond
>>>>>> ; rotates over more degrees than
>>>>>> lincs-warnangle          = 30
>>>>>> ; Convert harmonic bonds to morse potentials
>>>>>> morse                    = no
>>>>>>
>>>>>> ; ENERGY GROUP EXCLUSIONS
>>>>>> ; Pairs of energy groups for which all non-bonded interactions are
>>>>>> excluded
>>>>>> energygrp_excl           =
>>>>>>
>>>>>> ; NMR refinement stuff
>>>>>> ; Distance restraints type: No, Simple or Ensemble
>>>>>> disre                    = No
>>>>>> ; Force weighting of pairs in one distance restraint: Conservative or
>>>>>> Equal
>>>>>> disre-weighting          = Conservative
>>>>>> ; Use sqrt of the time averaged times the instantaneous violation
>>>>>> disre-mixed              = no
>>>>>> disre-fc                 = 1000
>>>>>> disre-tau                = 0
>>>>>> ; Output frequency for pair distances to energy file
>>>>>> nstdisreout              = 100
>>>>>> ; Orientation restraints: No or Yes
>>>>>> orire                    = no
>>>>>> ; Orientation restraints force constant and tau for time averaging
>>>>>> orire-fc                 = 0
>>>>>> orire-tau                = 0
>>>>>> orire-fitgrp             =
>>>>>> ; Output frequency for trace(SD) to energy file
>>>>>> nstorireout              = 100
>>>>>> ; Dihedral angle restraints: No, Simple or Ensemble
>>>>>> dihre                    = No
>>>>>> dihre-fc                 = 1000
>>>>>> dihre-tau                = 0
>>>>>> ; Output frequency for dihedral values to energy file
>>>>>> nstdihreout              = 100
>>>>>>
>>>>>> ; Free energy control stuff
>>>>>> free-energy              = no
>>>>>> init-lambda              = 0
>>>>>> delta-lambda             = 0
>>>>>> sc-alpha                 = 0
>>>>>> sc-sigma                 = 0.3
>>>>>>
>>>>>> ; Non-equilibrium MD stuff
>>>>>> acc-grps                 =
>>>>>> accelerate               =
>>>>>> freezegrps               =
>>>>>> freezedim                =
>>>>>> cos-acceleration         = 0
>>>>>>
>>>>>> ; Electric fields
>>>>>> ; Format is number of terms (int) and for all terms an amplitude
>>>
>>> (real)
>>>>>>
>>>>>> ; and a phase angle (real)
>>>>>> E-x                      =
>>>>>> E-xt                     =
>>>>>> E-y                      =
>>>>>> E-yt                     =
>>>>>> E-z                      =
>>>>>> E-zt                     =
>>>>>>
>>>>>> ; User defined thingies
>>>>>> user1-grps               =
>>>>>> user2-grps               =
>>>>>> userint1                 = 0
>>>>>> userint2                 = 0
>>>>>> userint3                 = 0
>>>>>> userint4                 = 0
>>>>>> userreal1                = 0
>>>>>> userreal2                = 0
>>>>>> userreal3                = 0
>>>>>> userreal4                = 0
>>>>>>
>>>>>>
>>>>>> In the log file it is written that RMS force on the shell is -nan and
>>>>
>>>> it
>>>>>>
>>>>>> can't do EM.
>>>>>> Can someone give me some advice in order to make EM possible?
>>>>>>
>>>>>
>>>>> Please provide full details about what the system is and how you built
>>>>> it.  Also note that using plain cutoff electrostatics went out of style
>>>>> about 20 years ago as it is horribly inaccurate.
>>>>>
>>>>> -Justin
>>>>>
>>>>> --
>>>>> ==================================================
>>>>>
>>>>> Justin A. Lemkul, Ph.D.
>>>>> Ruth L. Kirschstein NRSA Postdoctoral Fellow
>>>>>
>>>>> Department of Pharmaceutical Sciences
>>>>> School of Pharmacy
>>>>> Health Sciences Facility II, Room 629
>>>>> University of Maryland, Baltimore
>>>>> 20 Penn St.
>>>>> Baltimore, MD 21201
>>>>>
>>>>> jalemkul at outerbanks.umaryland.edu | (410) 706-7441
>>>>> http://mackerell.umaryland.edu/~jalemkul
>>>>>
>>>>> ==================================================
>>>>> --
>>>>> Gromacs Users mailing list
>>>>>
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>>>>>
>>>> --
>>>> Gromacs Users mailing list
>>>>
>>>> * Please search the archive at
>>>> http://www.gromacs.org/Support/Mailing_Lists/GMX-Users_List before
>>>> posting!
>>>>
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>>>> send a mail to gmx-users-request at gromacs.org.
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>>> --
>>> Gromacs Users mailing list
>>>
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>>> posting!
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>>>
>
> --
> ==================================================
>
> Justin A. Lemkul, Ph.D.
> Ruth L. Kirschstein NRSA Postdoctoral Fellow
>
> Department of Pharmaceutical Sciences
> School of Pharmacy
> Health Sciences Facility II, Room 629
> University of Maryland, Baltimore
> 20 Penn St.
> Baltimore, MD 21201
>
> jalemkul at outerbanks.umaryland.edu | (410) 706-7441
> http://mackerell.umaryland.edu/~jalemkul
>
> ==================================================
> --
> Gromacs Users mailing list
>
> * Please search the archive at
> http://www.gromacs.org/Support/Mailing_Lists/GMX-Users_List before posting!
>
> * Can't post? Read http://www.gromacs.org/Support/Mailing_Lists
>
> * For (un)subscribe requests visit
> https://maillist.sys.kth.se/mailman/listinfo/gromacs.org_gmx-users or send a
> mail to gmx-users-request at gromacs.org.


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